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Crenshaw, Albert G.
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Publications (10 of 54) Show all publications
Sandberg, C., Crenshaw, A. G., Elcadi, G., Christersson, C., Hlebowicz, J., Thilén, U. & Johansson, B. (2019). Slower Skeletal Muscle Oxygenation Kinetics in Adults With Complex Congenital Heart Disease. Canadian Journal of Cardiology
Open this publication in new window or tab >>Slower Skeletal Muscle Oxygenation Kinetics in Adults With Complex Congenital Heart Disease
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2019 (English)In: Canadian Journal of Cardiology, ISSN 0828-282X, E-ISSN 1916-7075Article in journal (Refereed) Epub ahead of print
Abstract [en]

Background: Adults with complex congenital heart disease (CHD) show reduced aerobic exercise capacity and impaired skeletal muscle function compared with healthy peers. Peripheral muscle factors are presumed to be important contributors to the aerobic capacity, but the mechanisms are poorly understood. The aim of the present study was to investigate differences between adults with CHD and controls in muscle oxygenation kinetics at rest, and during and after exercise.

Methods: Seventy-four patients with complex CHD (mean age 35.6±14.3 years, female n=22) were recruited. Seventy-four age- and sex-matched subjects were recruited as controls. Muscle oxygenation was successfully determined on the anterior portion of the deltoid muscle using near-infrared spectroscopy in 65 patients and 71 controls. Measurements were made at rest, during isotonic shoulder flexions (0-90°) to exhaustion, and during recovery.

Results: The patients with CHD performed fewer shoulder flexions (40±17 vs 69±40; P < 0.001), had lower muscle oxygen saturation (StO2) at rest (58±18% vs 69±18%; P < 0.001), slower desaturation rate at exercise onset (-9.7±5.9 vs -15.1±6.5% StO2 x 3.5 s-1, P <0.001), and slower resaturation rate post exercise (4.0±2.7 vs 5.4±3.6% StO2 x 3.5 s-1; P = 0.009) compared with the controls.

Conclusions: Comparison with age- and sex-matched controls, adults with complex CHD had slower oxygenation kinetics. This altered skeletal muscle metabolism might contribute to the impaired skeletal muscle endurance capacity shown and thereby also to the reduced aerobic capacity in this population.

National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:hig:diva-30661 (URN)10.1016/j.cjca.2019.05.001 (DOI)
Available from: 2019-09-17 Created: 2019-09-17 Last updated: 2019-09-26Bibliographically approved
Sandberg, C., Crenshaw, A. G., Elçadi, G. H., Christersson, C., Hlebowicz, J., Thilén, U. & Johansson, B. (2019). Slower Skeletal Muscle Oxygenation Kinetics in Adults With Complex Congenital Heart Disease. Canadian Journal of Cardiology
Open this publication in new window or tab >>Slower Skeletal Muscle Oxygenation Kinetics in Adults With Complex Congenital Heart Disease
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2019 (English)In: Canadian Journal of Cardiology, ISSN 0828-282X, E-ISSN 1916-7075Article in journal (Refereed) In press
Abstract [en]

Background: Adults with complex congenital heart disease (CHD) show reduced aerobic exercise capacity and impaired skeletal muscle function compared with healthy peers. Peripheral muscle factors are presumed to be important contributors to the aerobic capacity, but the mechanisms are poorly understood. The aim of the present study was to investigate differences between adults with CHD and controls in muscle oxygenation kinetics at rest, and during and after exercise.

Methods: Seventy-four patients with complex CHD (mean age 35.6 ± 14.3 years, female n = 22) were recruited. Seventy-four age- and sex-matched subjects were recruited as controls. Muscle oxygenation was successfully determined on the anterior portion of the deltoid muscle using near-infrared spectroscopy in 65 patients and 71 controls. Measurements were made at rest, during isotonic shoulder flexions (0-90°) to exhaustion, and during recovery.

Results: The patients with CHD performed fewer shoulder flexions (40 ± 17 vs 69 ± 40; P &lt; 0.001), had lower muscle oxygen saturation (StO2) at rest (58 ± 18% vs 69 ± 18%; P &lt; 0.001), slower desaturation rate at exercise onset (−9.7 ± 5.9 vs −15.1 ± 6.5% StO2 × 3.5 s−1, P &lt;0.001), and slower resaturation rate post exercise (4.0 ± 2.7 vs 5.4 ± 3.6% StO2 × 3.5 s−1; P = 0.009) compared with the controls. Conclusions: In comparison with age- and sex-matched controls, adults with complex CHD had slower oxygenation kinetics. This altered skeletal muscle metabolism might contribute to the impaired skeletal muscle endurance capacity shown and thereby also to the reduced aerobic capacity in this population. 

Place, publisher, year, edition, pages
Elsevier, 2019
National Category
Other Medical Sciences
Identifiers
urn:nbn:se:hig:diva-30630 (URN)10.1016/j.cjca.2019.05.001 (DOI)31473068 (PubMedID)2-s2.0-85071303990 (Scopus ID)
Available from: 2019-09-05 Created: 2019-09-05 Last updated: 2019-10-02Bibliographically approved
Sandberg, C., Crenshaw, A. G., Elcadi, G. H., Christensen, C., Hlebowicz, J., Thilén, U. & Johansson, B. (2018). Impaired skeletal muscle endurance in adults with complex congenital heart disease is associated with local muscle oxygenation. International Journal of Cardiology
Open this publication in new window or tab >>Impaired skeletal muscle endurance in adults with complex congenital heart disease is associated with local muscle oxygenation
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2018 (English)In: International Journal of Cardiology, ISSN 0167-5273, E-ISSN 1874-1754Article in journal (Refereed) Submitted
Keywords
Congenital heart disease, Muscle function, Muscle endurance, Muscle oxygenation, near-infrared spectroscopy
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:hig:diva-27641 (URN)
Available from: 2018-08-14 Created: 2018-08-14 Last updated: 2019-08-13Bibliographically approved
Sandberg, C., Crenshaw, A. G., Elcadi, G. H., Christersson, C., Hlebowicz, J., Thilén, U. & Johansson, B. (2018). Impaired Skeletal Muscle Endurance in Adults With Complex Congenital Heart Disease is Associated With Local Muscle Oxygenation Kinetics. In: Circulation: Abstracts From the American Heart Association's 2018 Scientific Sessions. Paper presented at American Heart Association's 2018, 10-14 November 2018, Chicago, IL, USA (pp. A15914). , 138, Article ID Suppl. 1.
Open this publication in new window or tab >>Impaired Skeletal Muscle Endurance in Adults With Complex Congenital Heart Disease is Associated With Local Muscle Oxygenation Kinetics
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2018 (English)In: Circulation: Abstracts From the American Heart Association's 2018 Scientific Sessions, 2018, Vol. 138, p. A15914-, article id Suppl. 1Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Introduction: Adults with complex congenital heart disease show reduced aerobic exercise capacity and impaired skeletal muscle function compared to healthy peers. Peripheral muscle factors are presumed to be important contributors, but the mechanisms are poorly understood. Hypothesis: Muscle oxygenation is associated with reduced skeletal muscle endurance in adults with complex CHD. Methods: Sixty-four adults with complex congenital heart disease (mean age 36.9±14.8 years, females n=19) were recruited from centers specialized in congenital heart disease. Seventy-four age and gender matched healthy peers were recruited as controls. Muscle oxygen saturation was successfully determined on the anterior portion of the deltoid muscle using near-infrared spectroscopy for 57 patients and 71 controls. Measurements were made at baseline, during isotonic shoulder flexions (0-90°) to exhaustion and during 60 seconds of recovery. Results: The adults with complex CHD performed fewer shoulder flexions (38±15 vs. 69±40, p <0.001), had lower muscle oxygen saturation at rest (58±17% vs. 69±18%, p <0.001), a slower desaturation rate at exercise onset (-9.5±5.9%/sec vs. -15.1±6.5%/sec, p <0.001), and a slower resaturation rate post exercise (3.9±2.8%/sec vs. 5.4±3.6%/sec, p =0.008) compared to the controls. Conclusions: A distinct association was found between muscle oxygenation kinetics and early muscle fatigue for adults with complex CHD. Our findings may give insight to the underlying mechanisms for the reduced aerobic exercise capacity for these patients, and therefore provide implications for design of exercise training protocols in this population. [ABSTRACT FROM AUTHOR]

Keywords
Adult congenital heart disease, Muscle, skeletal
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:hig:diva-30496 (URN)
Conference
American Heart Association's 2018, 10-14 November 2018, Chicago, IL, USA
Note

CONGENITAL HEART DISEASE AND PEDIATRIC CARDIOLOGY

SESSION TITLE: IT’S MORE THAN JUST SURVIVAL - KEY OUTCOMES

Available from: 2019-08-13 Created: 2019-08-13 Last updated: 2019-08-13Bibliographically approved
Gustafsson, P., Crenshaw, A. G., Edmunsson, D., Toolanen, G. & Crnalic, S. (2017). Muscle oxygenation in Type 1 diabetic and non-diabetic patients with and without chronic compartment syndrome. PLoS ONE, 12(10), Article ID e0186790.
Open this publication in new window or tab >>Muscle oxygenation in Type 1 diabetic and non-diabetic patients with and without chronic compartment syndrome
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2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 10, article id e0186790Article in journal (Refereed) Published
Abstract [en]

Background. Type 1 diabetic patients and non-diabetic patients were referred for evaluation for chronic exertional compartment syndrome (CECS) based on clinical examination and complaints of activity-related leg pain in the region of the tibialis anterior muscle. Previous studies using near-infrared spectroscopy (NIRS) showed greater deoxygenation during exercise for CECS patients versus healthy controls; however, this comparison has not been done for diabetic CECS patients.

Methods. We used NIRS to test for differences in oxygenation kinetics for Type 1 diabetic patients diagnosed with (CECS-diabetics, n = 9) versus diabetic patients without (CON-diabetics, n = 10) leg anterior chronic exertional compartment syndrome. Comparisons were also made between non-diabetic CECS patients (n = 11) and healthy controls (CON, n = 10). The experimental protocol consisted of thigh arterial cuff occlusion (AO, 1-minute duration), and treadmill running to reproduce symptoms. NIRS variables generated were resting StO2%, and oxygen recovery following AO. Also, during and following treadmill running the magnitude of deoxygenation and oxygen recovery, respectively, were determined.

Results. There was no difference in resting StO2%between CECS-diabetics (78.2±12.6%) vs. CONdiabetics (69.1±20.8%), or between CECS (69.3±16.2) vs. CON (75.9±11.2%). However, oxygen recovery following AO was significantly slower for CECS (1.8±0.8%/sec) vs. CON (3.8±1.7%/sec) (P = 0.002); these data were not different between the diabetic groups. StO2%during exercise was lower (greater deoxygenation) for CECS-diabetics (6.3±8.6%) vs. CON-diabetics (40.4±22.0%), and for CECS (11.3±16.8%) vs. CON (34.1±21.2%) (P<0.05 for both). The rate of oxygen recovery post exercise was faster for CECS-diabetics (3.5±2.6%/sec) vs. CON-diabetics (1.4±0.8%/sec) (P = 0.04), and there was a tendency of difference for CECS (3.1±1.4%/sec) vs. CON (1.9±1.3%/sec) (P = 0.05).

Conclusion. The greater deoxygenation during treadmill running for the CECS-diabetics group (vs. CON-diabetics) is in line with previous studies (and with the present study) that compared non-diabetic CECS patients with healthy controls. Our findings could suggest that NIRS may be useful as a diagnostic tool for assessing Type 1 diabetic patients suspected of CECS.

National Category
Orthopaedics
Identifiers
urn:nbn:se:hig:diva-25463 (URN)10.1371/journal.pone.0186790 (DOI)000413403000042 ()29059243 (PubMedID)2-s2.0-85032174485 (Scopus ID)
Available from: 2017-10-25 Created: 2017-10-25 Last updated: 2018-03-13Bibliographically approved
Gold, J., Hallman, D., Hellström, F., Björklund, M., Crenshaw, A. G., Mathiassen, S. E., . . . Ali, S. (2017). Systematic review of quantitative imaging biomarkers for neck and shoulder musculoskeletal disorders. BMC Musculoskeletal Disorders, 18, Article ID 395.
Open this publication in new window or tab >>Systematic review of quantitative imaging biomarkers for neck and shoulder musculoskeletal disorders
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2017 (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 18, article id 395Article, review/survey (Refereed) Published
Abstract [en]

Background

This study systematically summarizes quantitative imaging biomarker research in non-traumatic neck and shoulder musculoskeletal disorders (MSDs). There were two research questions: 1) Are there quantitative imaging biomarkers associated with the presence of neck and shoulder MSDs?, 2) Are there quantitative imaging biomarkers associated with the severity of neck and shoulder MSDs?

Methods

PubMed and SCOPUS were used for the literature search. One hundred and twenty-five studies met primary inclusion criteria. Data were extracted from 49 sufficient quality studies.

Results

Most of the 125 studies were cross-sectional and utilized convenience samples of patients as both cases and controls. Only half controlled for potential confounders via exclusion or in the analysis. Approximately one-third reported response rates. In sufficient quality articles, 82% demonstrated at least one statistically significant association between the MSD(s) and biomarker(s) studied. The literature synthesis suggested that neck muscle size may be decreased in neck pain, and trapezius myalgia and neck/shoulder pain may be associated with reduced vascularity in the trapezius and reduced trapezius oxygen saturation at rest and in response to upper extremity tasks. Reduced vascularity in the supraspinatus tendon may also be a feature in rotator cuff tears. Five of eight studies showed an association between a quantitative imaging marker and MSD severity.

Conclusions

Although research on quantitative imaging biomarkers is still in a nascent stage, some MSD biomarkers were identified. There are limitations in the articles examined, including possible selection bias and inattention to potentially confounding factors. Recommendations for future studies are provided.

Keywords
MRI, MSD, near-infrared spectroscopy, overuse, pain, PET/CT, thermography
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:hig:diva-20784 (URN)10.1186/s12891-017-1694-y (DOI)000410323900001 ()10.1186/s12891-017-1694-y (PubMedID)2-s2.0-85029322406 (Scopus ID)
Projects
ImagingBiorev
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2009-1761NIH (National Institute of Health), AR056019
Available from: 2015-12-04 Created: 2015-12-04 Last updated: 2018-11-26Bibliographically approved
Richter, H., Crenshaw, A. G., Domkin, D. & Elcadi, G. H. (2016). Near infrared spectroscopy as a useful research tool to measure prefrontal cortex activity during visually demanding near work. IIE Transactions on Occupational Ergonomics and Human Factors, 4(2-3), 164-174
Open this publication in new window or tab >>Near infrared spectroscopy as a useful research tool to measure prefrontal cortex activity during visually demanding near work
2016 (English)In: IIE Transactions on Occupational Ergonomics and Human Factors, ISSN 2157-7323, Vol. 4, no 2-3, p. 164-174Article in journal (Refereed) Published
Abstract [en]

Background: Unlike the usual skeletal muscles, ciliary muscles responsible for focusing the crystalline eye lens and extraocular muscles responsible for convergence eye movements appear resistant to fatigue. Purpose: The dual goals of this article are to briefly outline the current evidence that suggests that probing into blood flow and hemodynamic prefrontal brain activity with Near-Infrared Spectroscopy (fNIRS) could advance progress in visual ergonomic research, and to provide pilot data exemplifying the proposed approach. Methods: The vision task consisted of sustained focusing on a contrast-varying black and white Gabor grating. Four participants with a median age of 46 (IQR 44 – 50) fixated the grating from a distance of 65 cm. Three counterbalanced 10-min tasks required central fixation and accommodation/convergence on the grating target through: (i) 0.0 diopter (D) lenses, (ii) −1.5 D lenses, and (iii) −3.5yD lenses while maintaining maximal focus. Non-invasive measurements of local oxyhemoglobin (HbO2) were quantified with a one-channel Near Infrared Spectrometer, NIRS. The NIRS probe was placed on the prefrontal cortex in the vicinity of the right dorsolateral prefrontal cortex or Brodmann area 46 (DLPFC, BA 46). Accommodation response and contrast threshold was measured in parallel. Results: General estimating equation analyses showed that baseline subtracted DLPFC blood flow (ΔHbO2) increased significantly over time in all three lens conditions. The effect of time may be caused by a continuous increase in mental effort to compensate for progressively more mental fatigue induced by increased visual attention. The increase of DLPFC ΔHbO2 was also larger in magnitude in participants with larger amplitudes accommodation response (i.e., in participants who minimized deterioration in visual performance). Conclusion: The results from this study indicate that oxyhemoglobin changes recorded over DLPFC with NIRS can be used to assay the degree to which the visual system is strained during demanding near work.

Keywords
Attention fatigue, Accommodation, Compensatory effort, Discomfort, Electromyography, Mental fatigue, Near-Infrared Spectroscopy, Neck pain, Productivity, Visual ergonomics
National Category
Health Sciences
Identifiers
urn:nbn:se:hig:diva-18657 (URN)10.1080/21577323.2015.1067258 (DOI)000442406000008 ()
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2009-1761
Note

Accepted author version posted online.

Available from: 2015-01-01 Created: 2015-01-01 Last updated: 2019-03-26Bibliographically approved
Gold, J. E., Hallman, D., Hellström, F., Björklund, M., Crenshaw, A. G., Djupsjöbacka, M., . . . Barbe, M. F. (2016). Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders. Scandinavian Journal of Work, Environment and Health, 42(2), 103-124
Open this publication in new window or tab >>Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders
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2016 (English)In: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 42, no 2, p. 103-124Article, review/survey (Refereed) Published
Abstract [en]

Objective:  This study systematically summarizes biochemical biomarker research in non-traumatic musculoskeletal disorders (MSDs).  Two research questions guided the review:  1) Are there biochemical markers associated with neck and upper extremity MSDs? and, 2) Are there biochemical markers associated with the severity of neck and upper extremity MSDs? 

Methods:  A literature search was conducted in PubMed and SCOPUS.  Eighty-seven studies met primary inclusion criteria.  Following a quality screen, data were extracted from 44 sufficient quality articles.

Results:  Most of the 87 studies were cross-sectional and utilized convenience samples of patients as both cases and controls.  A response rate was explicitly stated in only 11 (13%) studies.  Less than half of the studies controlled for potential confounding through restriction or in the analysis.  Most sufficient quality studies were conducted in older populations (mean age in one or more analysis group > 50 yrs).

In sufficient quality articles, 82% demonstrated at least one statistically significant association between the MSD(s) and biomarker(s) studied.  Evidence suggested that: a) the collagen repair marker TIMP-1 is decreased in fibroproliferative disorders, b) 5-HT (serotonin) is increased in trapezius myalgia, and c) triglycerides are increased in a variety of MSDs.  Only five studies showed an association between a biochemical marker and MSD severity.

Conclusion: While some MSD biomarkers were identified, limitations in the articles examined included possible selection bias, confounding, spectrum effect (potentially heterogeneous biomarker associations in populations according to symptom severity or duration) and insufficient attention to co-morbid conditions. A list of recommendations for future studies is provided.

Keywords
collagen degradation and repair, inflammation, lipids, muscle injury, muscle metabolites, pain, serotonin, tendon injury, triglycerides
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:hig:diva-19271 (URN)10.5271/sjweh.3533 (DOI)000371449500002 ()26599377 (PubMedID)2-s2.0-84959483922 (Scopus ID)
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2009-1761
Available from: 2015-05-02 Created: 2015-05-02 Last updated: 2018-11-26Bibliographically approved
Elcadi, G., Forsman, M., Hallman, D., Aasa, U., Fahlström, M. & Crenshaw, A. (2014). Oxygenation and hemodynamics do not underlie early muscle fatigue for patients with work-related muscle pain. PLoS ONE, 9(4), e95582
Open this publication in new window or tab >>Oxygenation and hemodynamics do not underlie early muscle fatigue for patients with work-related muscle pain
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2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 4, p. e95582-Article in journal (Refereed) Published
Abstract [en]

Patients suffering from work-related muscle pain (WRMP) fatigue earlier during exercise than healthy controls. Inadequate oxygen consumption and/or inadequate blood supply can influence the ability of the muscles to withstand fatigue. However, it remains unknown if oxygenation and hemodynamics are associated with early fatigue in muscles of WRMP patients. In the present study we applied near-infrared spectroscopy (NIRS) on the extensor carpi radialis (ECR) and trapezius (TD) muscles of patients with WRMP (n = 18) and healthy controls (n = 17). Our objective was to determine if there were group differences in endurance times for a low-level contraction of 15% maximal voluntary contraction (MVC) – sustained for 12-13 min, and to see if these differences were associated with differences in muscle oxygenation and hemodynamics. At baseline, oxygen saturation (StO2%) was similar between groups for the ECR, but StO2% was significantly lower for TD for the WRMP patients (76%) compared to controls (85%) (P < 0.01). Also, baseline ECR blood flow was similar in the two groups. For both muscles there were a larger number of patients, compared to controls, that did not maintain the 15% MVC for the allotted time. Consequently, the endurance times were significantly shorter for the WRMP patients than controls (medians, ECR: 347 s vs. 582 s; TD: 430 s vs. 723 s respectively). Responses in StO2% during the contractions were not significantly different between groups for either muscle, i.e. no apparent difference in oxygen consumption. Overall, we interpret our findings to indicate that the early fatigue for our WRMP patients was not associated with muscle oxygenation and hemodynamics.

Keywords
Near Infrared Spectroscopy, Electromyography, muscle pain, trapezius, extensor carpi radialis, oxygenation, hemodynamics, fatigue
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:hig:diva-16596 (URN)10.1371/journal.pone.0095582 (DOI)000335240300056 ()24755957 (PubMedID)2-s2.0-84899705131 (Scopus ID)
Available from: 2014-04-30 Created: 2014-04-30 Last updated: 2018-03-13Bibliographically approved
Crenshaw, A., Fahlström, M. & Lyskov, E. (2013). A gender comparison of electromyography (EMG) during repetitive arm work with and without mental stress. Paper presented at Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), April 20-24, 2013, Boston, MA. The FASEB Journal, 27, 1152.21
Open this publication in new window or tab >>A gender comparison of electromyography (EMG) during repetitive arm work with and without mental stress
2013 (English)In: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 27, p. 1152.21-Article in journal, Meeting abstract (Other academic) Published
National Category
Other Medical Sciences
Identifiers
urn:nbn:se:hig:diva-17928 (URN)000319860505475 ()
Conference
Joint Annual Meeting of the ASPET/BPS at Experimental Biology (EB), April 20-24, 2013, Boston, MA
Available from: 2014-11-10 Created: 2014-11-10 Last updated: 2018-03-13Bibliographically approved
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