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Eriksson, Anders
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Eriksson, A., Kadi, F., Malm, C. & Thornell, L.-E. (2005). Skeletal muscle morphology in power-lifters with and without anabolic steroids.. Histochemistry and Cell Biology, 124(2), 167-175
Open this publication in new window or tab >>Skeletal muscle morphology in power-lifters with and without anabolic steroids.
2005 (English)In: Histochemistry and Cell Biology, ISSN 0948-6143, E-ISSN 1432-119X, Vol. 124, no 2, p. 167-175Article in journal (Refereed) Published
Abstract [en]

The morphological appearance of the vastus lateralis (VL) muscle from high-level power-lifters on long-term anabolic steroid supplementation (PAS) and power-lifters never taking anabolic steroids (P) was compared. The effects of long- and short-term supplementation were compared. Enzyme-immunohistochemical investigations were performed to assess muscle fiber type composition, fiber area, number of myonuclei per fiber, internal myonuclei, myonuclear domains and proportion of satellite cells. The PAS group had larger type I, IIA, IIAB and IIC fiber areas (p<0.05). The number of myonuclei/fiber and the proportion of central nuclei were significantly higher in the PAS group (p<0.05). Similar results were seen in the trapezius muscle (T) but additionally, in T the proportion of fibers expressing developmental myosin isoforms was higher in the PAS group compared to the P group. Further, in VL, the PAS group had significantly larger nuclear domains in fibers containing > or = 5 myonuclei. The results of AS on VL morphology in this study were similar to previously reported short-term effects of AS on VL. The initial effects from AS appear to be maintained for several years

Keywords
Adult, Anabolic Agents pharmacology, Cell Nucleus drug effects pathology, Humans, Male, Muscle Fibers drug effects metabolism, Muscle Fibers, Fast-Twitch drug effects metabolism pathology, Muscle Fibers, Slow-Twitch drug effects metabolism pathology, Muscle, Skeletal drug effects metabolism pathology, Myosins metabolism, Protein Isoforms metabolism, Weight Lifting
Identifiers
urn:nbn:se:hig:diva-2856 (URN)10.1007/s00418-005-0029-5 (DOI)000232530700009 ()16059740 (PubMedID)
Available from: 2007-11-28 Created: 2007-11-28 Last updated: 2018-03-13Bibliographically approved
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