This paper describes an evaluation of an alternative way to use an ordinary computer mouse. The function of the two mouse buttons were switched and the index finger operated the right button for normal clicking while the middle finger rested on the table directly to the right of the mouse. An electromyographic /EMG) evaluation of this alternative hand position in 29 subjects showed that the EMG activity in the extensor digitorum superficialis muscle was lower compared to a normal hand position both when the hand was resting on the mouse as well as during repeated clicking. All subjects showed a lower average EMG level during repeated clicking and 27 subjects reduced their activity when resting the hand on the mouse compared to a normal hand osition on the mouse.