hig.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard-cite-them-right
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • sv-SE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • de-DE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Isotopic Labeling Studies Reveal the Patulin Detoxification Pathway by the Biocontrol Yeast Rhodotorula kratochvilovae LS11
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Campus Universitario Río San Pedro, Puerto Real, Cádiz, Spain.
Högskolan i Gävle, Akademin för teknik och miljö, Avdelningen för elektroteknik, matematik och naturvetenskap, Biologi.ORCID-id: 0000-0002-8895-5631
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Campus Universitario Río San Pedro, Puerto Real, Cádiz, Spain.ORCID-id: 0000-0002-8612-0593
School of Chemistry, Biomedical Sciences Research Complex, University of St Andrews, Fife, Scotland.ORCID-id: 0000-0001-9869-8205
Vise andre og tillknytning
2018 (engelsk)Inngår i: Journal of Natural Products, ISSN 0163-3864, E-ISSN 1520-6025, Vol. 81, nr 12, s. 2692-2699Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Patulin (1) is a mycotoxin contaminant in fruit and vegetable products worldwide. Biocontrol agents, such as the yeast Rhodotorula kratochvilovae strain LS11, can reduce patulin (1) contamination in food. R. kratochvilovae LS11 converts patulin (1) into desoxypatulinic acid (DPA) (5), which is less cytotoxic than the mycotoxin (1) to in vitro human lymphocytes. In the present study, we report our investigations into the pathway of degradation of patulin (1) to DPA (5) by R. kratochvilovae. Isotopic labeling experiments revealed that 5 derives from patulin (1) through the hydrolysis of the γ-lactone ring and subsequent enzymatic modifications. The ability of patulin (1) and DPA (5) to cause genetic damage was also investigated by the cytokinesis-block micronucleus cytome assay on in vitro human lymphocytes. Patulin (1) was demonstrated to cause much higher chromosomal damage than DPA (5).

sted, utgiver, år, opplag, sider
2018. Vol. 81, nr 12, s. 2692-2699
HSV kategori
Identifikatorer
URN: urn:nbn:se:hig:diva-28699DOI: 10.1021/acs.jnatprod.8b00539ISI: 000454962500011PubMedID: 30460844Scopus ID: 2-s2.0-85059442745OAI: oai:DiVA.org:hig-28699DiVA, id: diva2:1266522
Merknad

Finansiärer:

MINECO  Grant no: AGL2015-65684-C2-1-R and HI2007-0026 

Italian Ministry of University and Research (Project PRIN) Grant no: 2006072204 

Tilgjengelig fra: 2018-11-28 Laget: 2018-11-28 Sist oppdatert: 2019-11-28bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Wright, Sandra A. I.

Søk i DiVA

Av forfatter/redaktør
Wright, Sandra A. I.Collado, Isidro G.Goss, Rebecca J. M.Durán-Patrón, Rosa
Av organisasjonen
I samme tidsskrift
Journal of Natural Products

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 8 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard-cite-them-right
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • sv-SE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • de-DE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf