This paper reviews three computer mouse studies in our laboratory where our emphasis was on mechanisms behind computer related disorders. Our approach was sequentially (i) to determine validity of a laboratory model of computer mouse use (painting rectangles) for studying musculoskeletal disorders; to use this model (ii) to study time pressure and precision demands on position sense and muscular oxygenation; and (iii) to determine the effect of pauses (active vs passive) on these parameters. (i) Kinematic data for the painting model showed constrained movements of the wrist similar to CAD work; a support for its validity for a real life situation. (ii) Changes in forearm oxygenation were associated with time pressure and precision demands; a potential for insight into the underlying pathophysiological mechanisms. (iii) Increasing trends in oxygenation and blood volume were associated with pauses, especially active; possible explanation for the alleviating effect of discomfort experienced in real life situations when a pause is implemented.