Nasir-ud-Din Muhammad Humayun (1508-1556), simply known as Humayun, was the second emperor of the Mughal Empire in India. He is often known with a discredited image in history even though recent investigations show a new, different, and regenerated perspective about him. This reconsideration is in relation to the philosophical, syncretic, and artistic pursuits and the spiritual heritage that he transmitted, which came to impact and define Mughal tradition and culture overall. Accordingly,  this thesis has on one hand the purpose to analyse and expose the not so much known “occult sciences” of Humayun, known as ‘ulum-i ghariba, which are defined in relation to their appliances and historical contexts, especially in relation to Sufism and Arabic Hermeticism. They are moreover explored in how they were experienced in the imperial administration of the early Mughal court. On the other hand, these “occult sciences” of Humayun are analysed and discussed in relation to the definitions of Western esotericism and practices of Renaissance Hermeticism as taught by Antoine Faivre, whose theory is employed for this thesis. The method used for this investigation combines a qualitative text analysis and a specific empirical approach with diachronic and synchronic applications. The result of this research shows that the “occult sciences” of Humayun help to define and confirm a wider study field of “comparative esotericism”, which goes beyond the borders of the Western culture, and which is found with its unique interpretations as an esoteric expression within Islam, and specifically at the dawn of the Mughal tradition.