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Risk factors for lower health-related QoL after allogeneic stem cell transplantation in children
Stockholms universitet, Institutionen för socialt arbete - Socialhögskolan.
2007 (English)In: Pediatric Transplantation, ISSN 1397-3142, E-ISSN 1399-3046, Vol. 11, no 2, p. 145-151Article in journal (Refereed) Published
Abstract [en]

To explore risk factors affecting HrQoL, we analyzed data from patients (n = 51) at least three yr beyond SCT and their parents (n = 41), who responded to the SCHQ, to a subjective symptom inventory and to a sense of coherence instrument, in parallel with a physician-rated scoring of late effects. Children with leukemia rated a lower HrQoL than children with non-malignant disease only in subscale RE, limitations in role socially because of the emotional difficulties (p < 0.05) but had more severe late effects (p < 0.05). Parents of children with leukemia rated their children's HrQoL overall lower in both the psychosocial area and physical area (p < 0.01) and the child's condition also had a greater impact on parents' emotional situation (p < 0.05), compared with parents of children with non-malignant diagnosis. The psychosocial HrQoL was more affected in recipients of an unrelated than of a sibling graft, according to both child (p < 0.01) and parent (p < 0.05). In the multiple regression analysis, however, late effects remained the only independent factor, contributing to low parental psychosocial (p < 0.05) and physical (p < 0.001) HrQoL ratings, while leukemia, unrelated donor and TBI did not. To conclude, parent-reported HrQoL was lower in SCT patients with leukemia, mainly due to a higher impact of late effects in this group.

Place, publisher, year, edition, pages
2007. Vol. 11, no 2, p. 145-151
Keywords [en]
Health-related, QoL, Bonemarow transplantation, risk factors
National Category
Other Medical Sciences
Identifiers
URN: urn:nbn:se:hig:diva-28627DOI: 10.1111/j.1399-3046.2006.00630.xISI: 000243792400007OAI: oai:DiVA.org:hig-28627DiVA, id: diva2:1265445
Available from: 2007-12-19 Created: 2018-11-23Bibliographically approved

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Forinder, Ulla

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  • apa
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