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Association between prescribed antidepressants and other prescribed drugs differ by gender : a nationwide register-based study in Sweden
University of Gävle, Faculty of Health and Occupational Studies, Department of Health and Caring Sciences, Caring science.ORCID iD: 0000-0003-4877-506x
University of Gävle, Faculty of Health and Occupational Studies, Department of Health and Caring Sciences, Caring science.
2019 (English)In: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725Article in journal (Refereed) Epub ahead of print
Abstract [en]

Background: People with depression are prescribed more drugs than people in general,partly due to comorbidity with other conditions. However, little research has been done on depression-related drug use from a gender perspective.

Aim: Examine the association between antidepressants, other types of prescribed drugs, and polypharmacy, by gender.

Methods: Data on drugs dispensed October to December 2016 to all Swedish citizens aged 18-84 years were collected from the Swedish prescribed drug register. Logistic regression analyses were performed to examine the associations between antidepressantsand other drugs, by gender.

Results: For both men and women, associations were found between antidepressants and drugs for alimentary tract problems, respiratory problems, blood, nervous system, analgesics, and polypharmacy. However, for women, but not men, associations were alsofound for drugs for diabetes, musculoskeletal problems, dermatological problems, and systemic hormones. 

Conclusions: Associations were found between antidepressants and many other types of drugs for both men and women; indicating comorbidity between depression and other conditions.Further, several of the associations between antidepressants and other drugs were found to be specific among women. Whether this indicates that men and women differ in comorbidity between depression and other conditions cannot be concluded based on this cross-sectional study. However, comorbidity impairs the possibility of recovery; in the somatic condition as well as the depression. Thus,physicians need to be aware of that the association between antidepressants and other types of drugs are more common among women than men.

Place, publisher, year, edition, pages
2019.
Keywords [en]
Gender, Antidepressants, Prescribed drugs, Polypharmacy
National Category
Other Medical Sciences
Identifiers
URN: urn:nbn:se:hig:diva-28679DOI: 10.1080/08039488.2018.1536766PubMedID: 30661437Scopus ID: 2-s2.0-85060341279OAI: oai:DiVA.org:hig-28679DiVA, id: diva2:1266155
Available from: 2018-11-27 Created: 2018-11-27 Last updated: 2019-03-01Bibliographically approved

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Sundbom Thunander, LenaHedborg, Kerstin

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