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Systematic review of biochemical biomarkers for neck and upper-extremity musculoskeletal disorders
Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.ORCID-id: 0000-0003-1062-0134
Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.ORCID-id: 0000-0002-2741-1868
Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning.ORCID-id: 0000-0002-4556-2846
Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för arbets- och folkhälsovetenskap, Arbetshälsovetenskap. Högskolan i Gävle, Centrum för belastningsskadeforskning. Department of Community Medicine and Rehabilitation, Physiotherapy, Umea University, Umeå Sweden.ORCID-id: 0000-0001-7543-4397
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2016 (engelsk)Inngår i: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 42, nr 2, s. 103-124Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Objective:  This study systematically summarizes biochemical biomarker research in non-traumatic musculoskeletal disorders (MSDs).  Two research questions guided the review:  1) Are there biochemical markers associated with neck and upper extremity MSDs? and, 2) Are there biochemical markers associated with the severity of neck and upper extremity MSDs? 

Methods:  A literature search was conducted in PubMed and SCOPUS.  Eighty-seven studies met primary inclusion criteria.  Following a quality screen, data were extracted from 44 sufficient quality articles.

Results:  Most of the 87 studies were cross-sectional and utilized convenience samples of patients as both cases and controls.  A response rate was explicitly stated in only 11 (13%) studies.  Less than half of the studies controlled for potential confounding through restriction or in the analysis.  Most sufficient quality studies were conducted in older populations (mean age in one or more analysis group > 50 yrs).

In sufficient quality articles, 82% demonstrated at least one statistically significant association between the MSD(s) and biomarker(s) studied.  Evidence suggested that: a) the collagen repair marker TIMP-1 is decreased in fibroproliferative disorders, b) 5-HT (serotonin) is increased in trapezius myalgia, and c) triglycerides are increased in a variety of MSDs.  Only five studies showed an association between a biochemical marker and MSD severity.

Conclusion: While some MSD biomarkers were identified, limitations in the articles examined included possible selection bias, confounding, spectrum effect (potentially heterogeneous biomarker associations in populations according to symptom severity or duration) and insufficient attention to co-morbid conditions. A list of recommendations for future studies is provided.

sted, utgiver, år, opplag, sider
2016. Vol. 42, nr 2, s. 103-124
Emneord [en]
collagen degradation and repair, inflammation, lipids, muscle injury, muscle metabolites, pain, serotonin, tendon injury, triglycerides
HSV kategori
Identifikatorer
URN: urn:nbn:se:hig:diva-19271DOI: 10.5271/sjweh.3533ISI: 000371449500002PubMedID: 26599377Scopus ID: 2-s2.0-84959483922OAI: oai:DiVA.org:hig-19271DiVA, id: diva2:809357
Forskningsfinansiär
Forte, Swedish Research Council for Health, Working Life and Welfare, 2009-1761Tilgjengelig fra: 2015-05-02 Laget: 2015-05-02 Sist oppdatert: 2018-11-26bibliografisk kontrollert

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Gold, Judith EHallman, DavidHellström, FredrikBjörklund, MartinCrenshaw, Albert G.Djupsjöbacka, MatsHeiden, MarinaMathiassen, Svend Erik

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