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Considerations on Circuit Design and Data Acquisition of a Portable Surface Plasmon Resonance Biosensing System
Department of Electrical Engineering, Henan Agricultural University, Zhengzhou, China.
Department of Electrical Engineering, Henan Agricultural University, Zhengzhou, China.
Department of Electrical Engineering, Henan Agricultural University, Zhengzhou, China.
Department of Electrical Engineering, Henan Agricultural University, Zhengzhou, China.
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2015 (Engelska)Ingår i: Sensors, ISSN 1424-8220, E-ISSN 1424-8220, Vol. 15, nr 8, s. 20511-20523Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The aim of this study was to develop a circuit for an inexpensive portable biosensing system based on surface plasmon resonance spectroscopy. This portable biosensing system designed for field use is characterized by a special structure which consists of a microfluidic cell incorporating a right angle prism functionalized with a biomolecular identification membrane, a laser line generator and a data acquisition circuit board. The data structure, data memory capacity and a line charge-coupled device (CCD) array with a driving circuit for collecting the photoelectric signals are intensively focused on and the high performance analog-to-digital (A/D) converter is comprehensively evaluated. The interface circuit and the photoelectric signal amplifier circuit are first studied to obtain the weak signals from the line CCD array in this experiment. Quantitative measurements for validating the sensitivity of the biosensing system were implemented using ethanol solutions of various concentrations indicated by volume fractions of 5%, 8%, 15%, 20%, 25%, and 30%, respectively, without a biomembrane immobilized on the surface of the SPR sensor. The experiments demonstrated that it is possible to detect a change in the refractive index of an ethanol solution with a sensitivity of 4.99838 × 10(5) ΔRU/RI in terms of the changes in delta response unit with refractive index using this SPR biosensing system, whereby the theoretical limit of detection of 3.3537 × 10(-5) refractive index unit (RIU) and a high linearity at the correlation coefficient of 0.98065. The results obtained from a series of tests confirmed the practicality of this cost-effective portable SPR biosensing system.

Ort, förlag, år, upplaga, sidor
2015. Vol. 15, nr 8, s. 20511-20523
Nyckelord [en]
ADC conversion time, biosensing system, linear CCD array, microcontroller, refractive index, surface plasmon resonance
Nationell ämneskategori
Annan elektroteknik och elektronik Biomedicinsk laboratorievetenskap/teknologi
Identifikatorer
URN: urn:nbn:se:hig:diva-20199DOI: 10.3390/s150820511ISI: 000360906500137PubMedID: 26295398Scopus ID: 2-s2.0-84939824326OAI: oai:DiVA.org:hig-20199DiVA, id: diva2:851063
Anmärkning

Funding Agency:

Grant Number National Natural Science Foundation of China  Grant no: U1304305 

State Key Laboratory of Wheat and Maize Crop Science Grant no: SKL2014ZH-06 

Henan Province Science and Technology Cooperation Program Grant no: 132106000073 

Tillgänglig från: 2015-09-03 Skapad: 2015-09-03 Senast uppdaterad: 2018-03-13Bibliografiskt granskad

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Liang, Hao

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