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Cohort Effects in the Prevalence and Survival of People with Dementia in a Rural Area in Northern Sweden
Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden; Center for Alzheimer Research at Karolinska Institutet, Stockholm, Sweden; Centre for Research & Development, Uppsala University/County Council of Gävleborg, Sjukhuset i Gävle, Sweden.
Högskolan i Gävle, Akademin för hälsa och arbetsliv, Avdelningen för hälso- och vårdvetenskap, Medicin- och vårdvetenskap. Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden.ORCID-id: 0000-0002-4621-3816
Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden.
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2016 (Engelska)Ingår i: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 50, nr 2, s. 387-396Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Recent studies suggest that trends in cardiovascular risk may result in a decrease in age-specific prevalence of dementia. Studies in rural areas are rare.

Objectives: To study cohort effects in dementia prevalence and survival of people with dementia in a Swedish rural area.

Methods: Participants were from the 1995-1998 Nordanstig Project (NP) (n = 303) and the 2001-2003 Swedish National study on Aging and Care in Nordanstig (SNAC-N) (n = 384). Overall 6-year dementia prevalence and mortality in NP and SNAC-N were compared for people 78 years and older. Logistic regression analyses were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for dementia occurrence using the NP study population as the reference group. Cox regression models were used to analyze time to death.

Results: The crude prevalence of dementia was 21.8% in NP and 17.4% in SNAC-N. When the NP cohort was used as the reference group, the age- and gender-adjusted OR of dementia was 0.71 (95% CI 0.48-1.04) in SNAC-N; the OR was 0.47 (0.24-0.90) for men and 0.88 (0.54-1.44) for women. In the extended model, the OR of dementia was significantly lower in SNAC-N than in the NP cohort as a whole (0.63; 0.39-0.99) and in men (0.34; 0.15-0.79), but not in women (0.81; 0.46-1.44). The Cox regression models indicated that the hazard ratio of dying was lower in the SNAC-N than NP population.

Conclusions: Trends toward a lower prevalence of dementia in high-income countries seem to be evident in this Swedish rural area, at least in men.

Ort, förlag, år, upplaga, sidor
2016. Vol. 50, nr 2, s. 387-396
Nyckelord [en]
Dementia, mortality, prevalence, rural population
Nationell ämneskategori
Geriatrik
Identifikatorer
URN: urn:nbn:se:hig:diva-20887DOI: 10.3233/JAD-150708ISI: 000368929200006PubMedID: 26639970Scopus ID: 2-s2.0-84970917672OAI: oai:DiVA.org:hig-20887DiVA, id: diva2:890296
Projekt
Physical functioning in old age: temporal trends and geographical variation in Sweden
Forskningsfinansiär
Forte, Forskningsrådet för hälsa, arbetsliv och välfärdVetenskapsrådetTillgänglig från: 2016-01-02 Skapad: 2015-12-16 Senast uppdaterad: 2019-10-11Bibliografiskt granskad

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