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Short-term olfactory sensitization involves brain networks relevant for pain, and indicates chemical intolerance
University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences, Occupational health science. University of Gävle, Centre for Musculoskeletal Research. Department of Psychology, Umeå University, Umeå, Sweden.
Department of Psychology, Umeå University, Umeå, Sweden.
Department of Integrative Medical Biology and Physiology, Umeå University, Umeå, Sweden; Department of Radiation Sciences, Umeå University, Umeå, Sweden.
Department of Psychology, Umeå University, Umeå, Sweden.
2017 (English)In: International journal of hygiene and environmental health (Print), ISSN 1438-4639, E-ISSN 1618-131X, Vol. 220, no 2, 503-509 p.Article in journal (Refereed) Published
Abstract [en]

Chemical intolerance is a medically unexplained affliction that implies deleterious reactions to non-toxic everyday chemical exposure. Sensitization (i.e. increased reactivity to repeated, invariant stimulation) to odorous stimulation is an important component in theoretical explanations of chemical intolerance, but empirical evidence is scarce. We hypothesized that (1) individuals who sensitize to repeated olfactory stimulation, compared with those who habituate, would express a lower blood oxygenated level dependent (BOLD) response in key inhibitory areas such as the rACC, and higher signal in pain/saliency detection regions, as well as primary and/or secondary olfactory projection areas; and (2) olfactory sensitization, compared with habituation, would be associated with greater self-reported chemical intolerance. Moreover, we assessed whether olfactory sensitization was paralleled by comparable trigeminal processing – in terms of perceptual ratings and BOLD responses. We grouped women from a previous functional magnetic imaging study based on intensity ratings of repeated amyl acetate exposure over time. Fourteen women sensitized to the exposure, 15 habituated, and 20 were considered “intermediate” (i.e. neither sensitizers nor habituaters). Olfactory sensitizers, compared with habituaters, displayed a BOLD-pattern in line with the hypothesis, and reported greater problems with odours in everyday life. They also expressed greater reactions to CO2 in terms of both perceived intensity and BOLD signal. The similarities with pain are discussed.

Place, publisher, year, edition, pages
2017. Vol. 220, no 2, 503-509 p.
Keyword [en]
Chemical intolerance; FMRI; Olfactory; Sensitization; Smell; Trigeminal
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:hig:diva-23609DOI: 10.1016/j.ijheh.2017.02.002ISI: 000401215300022PubMedID: 28254164Scopus ID: 2-s2.0-85013106506OAI: oai:DiVA.org:hig-23609DiVA: diva2:1073667
Funder
Riksbankens Jubileumsfond, M14-0375:1
Note

Funding agencies:

Swedish Asthma and Allergy Association's Research Fund  No: 2007064-K 

European territorial cooperation program Botnia-Atlantica  No: 162621 

Region Vasterbotten  No: 201126 

Available from: 2017-02-13 Created: 2017-02-13 Last updated: 2017-06-30Bibliographically approved

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Citation style
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