Background: Socioeconomic status has been found to have a significant impact on the health as well as risk behaviors of adolescents across different contexts. This study was conducted to assess the effect of social relations adjusted by social class on physical and psychological well-being of adolescences in Teheran, Iran. Methods: This was a cross- sectional study and carried out on 1,742 adolescences living in Tehran during 2011. Adolescences were selected, using proportional stratified sampling method and a questionnaire was filled over an interview for data gathering. Data were analyzed, using SPSS18 logistic regression. Results: The prevalence of psychological symptoms was more than 24% and had a large range (24%-93%), while physical symptoms showed a lower prevalence with a smaller range (12%-33%). Furthermore, there was a significant relation between the adolescences gender and feeling the need for others' help (p<0.001). Factors related to feeling the need for others help, anxiety, and worrying were the most prevalent among both boys and girls. In the section of family social relations, talking to the mother and talking to the father had the lowest and the highest prevalence among girls and boys, respectively. With respect to relations, the number of close friends and after school gathering time with close friends had the highest prevalence among girls, while the number of close friends and E-communication with close friends had the lowest and the highest prevalence among boys, respectively. Conclusion: The physical and psychological symptoms were common among adolescents from families with high socioeconomic status.