There is a great debate considering social work related to health issues, wellbeing and sustainable development. This chapter examines possibilities and limitations of using a multidimensional perspective to explore and analyse use and misuse of alcohol, based on self-theoretical reasoning, gives a more detailed and specific understanding of substance users who represent a heterogeneous population, and of substance use-related dependency problems and their treatment to restore health and wellbeing and more sustainable life situations. Such an approach describes and analyses drug-use related problems in a manner that provides holistic information and relevant knowledge about persons and situational interaction processes that are involved in the use and misuse of alchol and drugs and its treatment. Tentative conclusions are presented.