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Glutamate and prostaglandin E2 in the trapezius muscle of female subjects with chronic muscle pain and controls determined by microdialysis.
University of Gävle, Belastningsskadecentrum.
University of Gävle, Belastningsskadecentrum.
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2005 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 9, no 5, 511-515 p.Article in journal (Refereed) Published
Abstract [en]

Much is still unknown concerning the mechanisms underlying the development of chronic muscle pain. The presence and magnitude of inflammatory substances and neurotransmitters in chronic painful conditions is not clear. The aims of the present study were to determine, with the use of microdialysis, the interstitial concentrations and the equilibration times for PGE(2) and glutamate in the trapezius muscles of nine female subjects with chronic muscle pain, and nine pain-free age-matched controls. A microdialysis probe was implanted in the upper part of the trapezius muscle and perfused with Ringer-acetate solution at a flow rate of 0.3 muL/min. Samples were obtained every 30 min, during a 4-h rest period. At equilibration, the mean concentrations (+/-SE) of PGE(2) were 0.71 (+/-0.11) ng/mL for the pain-group and 0.97 (+/-0.35) ng/mL for the controls. For glutamate the mean concentrations for the pain-group were 66.3 (+/-13.3) mumol/L and 60.6 (+/-22.9) mumol/L for the controls. For the pain group and the control group, respectively, equilibration for PGE(2) was reached at 180 and 150 min, and for glutamate at 150 and 120 min. The present study showed no differences between groups in the concentrations of PGE(2) and glutamate in the trapezius muscle. Further, it revealed that when using the slow-flow method, a period of at least 2.0-2.5 h is needed, after probe insertion, to reach steady state for glutamate and PGE(2).

Place, publisher, year, edition, pages
2005. Vol. 9, no 5, 511-515 p.
Keyword [en]
Adult, Chronic Disease, Dinoprostone metabolism, Extracellular Fluid chemistry metabolism, Female, Fibromyalgia metabolism physiopathology, Glutamic Acid metabolism, Homeostasis physiology, Humans, Microdialysis, Middle Aged, Muscle, Skeletal chemistry metabolism physiopathology, Neck Pain etiology metabolism physiopathology, Shoulder Pain etiology metabolism physiopathology, Time Factors
Identifiers
URN: urn:nbn:se:hig:diva-2768DOI: 10.1016/j.ejpain.2004.11.004ISI: 000232054100003PubMedID: 16139179OAI: oai:DiVA.org:hig-2768DiVA: diva2:119430
Available from: 2007-11-28 Created: 2007-11-28 Last updated: 2015-11-11Bibliographically approved

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Flodgren, Gerd MCrenshaw, Albert GHellström, Fredrik BDjupsjöbacka, Mats
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