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Acute muscle inflammation enhances the monosynaptic reflexes and c-fos expression in the feline spinal cord
Zentrum Physiologie und Pathophysiologie, Universität Göttingen, Göttingen, Germany.
Zentrum Physiologie und Pathophysiologie, Universität Göttingen, Göttingen, Germany.
Department of Movement Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Kiev, Ukraine.
Department of Movement Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Kiev, Ukraine.
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2007 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 11, no 5, 579-586 p.Article in journal (Refereed) Published
Abstract [en]

The aim of this research was to study the changes of the motor reflex activity (monosynaptic reflex (MSR) of the flexor and extensor muscles) and Fos immunoreactivity in lumbo-sacral spinal cord after acute induced myositis of m. gastrocnemius-soleus (GS). The experiments were carried out on ischaemic decerebrated, spinalized in C1 cats. After infiltration of the GS muscle with carrageenan (2%) MSRs of flexors and extensors showed a significant increase in amplitude +127+/-24.5% and +155+/-28.5%, respectively, p<0.05. The exposed effect was initiated within 30 min and achieved a maximum 2.8h after the intramuscular injections of carrageenan. After analysis of dynamics of the MSRs, animals were perfused and c-fos expression in the spinal segments L6-S1 was evaluated. In comparison to sham-operated animals, the number of Fos-immunoreactive (Fos-ir) cells was noticeably increased in the lumbar cord of cats with carrageenan-induced myositis. The labeled cells were concentrated in the ipsilateral laminae I/II, neck of the dorsal horn (V/VI) and intermediate zone (VII), however, clear predominance of their concentration was found in the deep laminae. The effect of muscle inflammation was also expressed as a significant decline in the number of NADPH-d-reactive cells (p<0.05) in ipsilateral laminae I/II of L6/L7. The results show that the input from acutely inflamed muscles may induce an increase of the reflex responsiveness of flexors and extensors which is not mediated via the gamma-spindle-loop and which coincides with a significant increase in c-fos expression in the deep laminae of the lumbar spinal cord.

Place, publisher, year, edition, pages
2007. Vol. 11, no 5, 579-586 p.
Keyword [en]
Action Potentials physiology, Afferent Pathways metabolism physiopathology, Animals, Biological Markers analysis metabolism, Carrageenan pharmacology, Cats, Functional Laterality physiology, Inflammation Mediators pharmacology, Muscle Contraction physiology, Muscle, Skeletal innervation physiopathology, Myositis physiopathology, NADPH Dehydrogenase metabolism, Neurons, Afferent metabolism, Nociceptors physiology, Peripheral Nerves metabolism physiopathology, Posterior Horn Cells metabolism, Proto-Oncogene Proteins c-fos metabolism, Reflex, Abnormal physiology, Reflex, Monosynaptic physiology, Spinal Cord cytology metabolism physiopathology, Up-Regulation physiology
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:hig:diva-2879DOI: 10.1016/j.ejpain.2006.09.004ISI: 000247000300013PubMedID: 17118680Scopus ID: 2-s2.0-34247578200OAI: oai:DiVA.org:hig-2879DiVA: diva2:119541
Available from: 2007-11-28 Created: 2007-11-28 Last updated: 2016-10-30Bibliographically approved

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CiteExportLink to record
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