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Isotopic Labeling Studies Reveal the Patulin Detoxification Pathway by the Biocontrol Yeast Rhodotorula kratochvilovae LS11
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Campus Universitario Río San Pedro, Puerto Real, Cádiz, Spain.
University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences, Biology.ORCID iD: 0000-0002-8895-5631
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Campus Universitario Río San Pedro, Puerto Real, Cádiz, Spain.ORCID iD: 0000-0002-8612-0593
School of Chemistry, Biomedical Sciences Research Complex, University of St Andrews, Fife, Scotland.ORCID iD: 0000-0001-9869-8205
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2018 (English)In: Journal of Natural Products, ISSN 0163-3864, E-ISSN 1520-6025, Vol. 81, no 12, p. 2692-2699Article in journal (Refereed) Published
Abstract [en]

Patulin (1) is a mycotoxin contaminant in fruit and vegetable products worldwide. Biocontrol agents, such as the yeast Rhodotorula kratochvilovae strain LS11, can reduce patulin (1) contamination in food. R. kratochvilovae LS11 converts patulin (1) into desoxypatulinic acid (DPA) (5), which is less cytotoxic than the mycotoxin (1) to in vitro human lymphocytes. In the present study, we report our investigations into the pathway of degradation of patulin (1) to DPA (5) by R. kratochvilovae. Isotopic labeling experiments revealed that 5 derives from patulin (1) through the hydrolysis of the γ-lactone ring and subsequent enzymatic modifications. The ability of patulin (1) and DPA (5) to cause genetic damage was also investigated by the cytokinesis-block micronucleus cytome assay on in vitro human lymphocytes. Patulin (1) was demonstrated to cause much higher chromosomal damage than DPA (5).

Place, publisher, year, edition, pages
2018. Vol. 81, no 12, p. 2692-2699
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:hig:diva-28699DOI: 10.1021/acs.jnatprod.8b00539ISI: 000454962500011PubMedID: 30460844Scopus ID: 2-s2.0-85059442745OAI: oai:DiVA.org:hig-28699DiVA, id: diva2:1266522
Note

Finansiärer:

MINECO  Grant no: AGL2015-65684-C2-1-R and HI2007-0026 

Italian Ministry of University and Research (Project PRIN) Grant no: 2006072204 

Available from: 2018-11-28 Created: 2018-11-28 Last updated: 2019-03-01Bibliographically approved

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Wright, Sandra A. I.

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