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Impaired Skeletal Muscle Endurance in Adults With Complex Congenital Heart Disease is Associated With Local Muscle Oxygenation Kinetics
Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden.
University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences, Occupational Health Science. University of Gävle, Centre for Musculoskeletal Research.
University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences, Occupational Health Science. University of Gävle, Centre for Musculoskeletal Research.ORCID iD: 0000-0001-5005-9957
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
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2018 (English)In: Circulation: Abstracts From the American Heart Association's 2018 Scientific Sessions, 2018, Vol. 138, p. A15914-, article id Suppl. 1Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Introduction: Adults with complex congenital heart disease show reduced aerobic exercise capacity and impaired skeletal muscle function compared to healthy peers. Peripheral muscle factors are presumed to be important contributors, but the mechanisms are poorly understood. Hypothesis: Muscle oxygenation is associated with reduced skeletal muscle endurance in adults with complex CHD. Methods: Sixty-four adults with complex congenital heart disease (mean age 36.9±14.8 years, females n=19) were recruited from centers specialized in congenital heart disease. Seventy-four age and gender matched healthy peers were recruited as controls. Muscle oxygen saturation was successfully determined on the anterior portion of the deltoid muscle using near-infrared spectroscopy for 57 patients and 71 controls. Measurements were made at baseline, during isotonic shoulder flexions (0-90°) to exhaustion and during 60 seconds of recovery. Results: The adults with complex CHD performed fewer shoulder flexions (38±15 vs. 69±40, p <0.001), had lower muscle oxygen saturation at rest (58±17% vs. 69±18%, p <0.001), a slower desaturation rate at exercise onset (-9.5±5.9%/sec vs. -15.1±6.5%/sec, p <0.001), and a slower resaturation rate post exercise (3.9±2.8%/sec vs. 5.4±3.6%/sec, p =0.008) compared to the controls. Conclusions: A distinct association was found between muscle oxygenation kinetics and early muscle fatigue for adults with complex CHD. Our findings may give insight to the underlying mechanisms for the reduced aerobic exercise capacity for these patients, and therefore provide implications for design of exercise training protocols in this population. [ABSTRACT FROM AUTHOR]

Place, publisher, year, edition, pages
2018. Vol. 138, p. A15914-, article id Suppl. 1
Keywords [en]
Adult congenital heart disease, Muscle, skeletal
National Category
Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:hig:diva-30496OAI: oai:DiVA.org:hig-30496DiVA, id: diva2:1342543
Conference
American Heart Association's 2018, 10-14 November 2018, Chicago, IL, USA
Note

CONGENITAL HEART DISEASE AND PEDIATRIC CARDIOLOGY

SESSION TITLE: IT’S MORE THAN JUST SURVIVAL - KEY OUTCOMES

Available from: 2019-08-13 Created: 2019-08-13 Last updated: 2019-08-13Bibliographically approved

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Crenshaw, Albert G.Elcadi, Guilherme H.

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