In this research work, steel plate girders (SPGs) having the web openings with the elliptical shape are analysed. The finite element ABAQUS software is applied. An experimentally tested SPG is used for the modelling verification. Then, the SPGs are developed. Three-dimensional (3D) finite element models of the SPGs are analysed nonlinearly considering various variables. The variables are adopted in order to deeply examine the performance of the SPGs using the finite element method. These variables include: 1) number of the openings, 2) arrangement of the openings, 3) using steel frame around the openings, 4) utilising diagonal steel stiffeners to connect the steel frame around the openings to the corners of the SPGs, and 5) thicknesses of the steel frame and the diagonal steel stiffeners. The obtained results are compared and discussed considering the effects of the variables. It is concluded that increasing the number of the openings has an adverse impact on the ultimate strength of the SPGs. The arrangement of the openings in the SPGs significantly affects their performance. The horizontal openings are superior to the vertical ones. Utilising the steel frame around the openings and/or the steel stiffeners improves the ultimate strength. Enhancing the thickness of the steel frame and/or stiffeners increases the ultimate strength. The assessment of the failure modes of the SPGs is also done.