Recent corporate scandals have prompted discussion of the role of business in society. Business leaders are increasingly held accountable for their actions and non-actions in relation to all stakeholders, both internal and external. The emerging challenges faced by business organizations today include economic, social, and environmental demands; globalization; rapid population growth; natural resources exploitation; extreme poverty and debt; global migration; unprecedented inequality; global migration; geopolitical and ecological crises; climate change and other environmental issues; competitive pressure; health issues; new information and communication technologies; and sustainable lifestyles. Responsible leadership represents a new type of leadership, which is better positioned to address these challenges through stakeholder consideration and in the context of sustainable development. Building on existing literature, the aim of this article is to present a conceptual framework of responsible leadership as a potential determinant of stakeholders' health and well-being.