This paper presents a new strategy and circuit configuration composed of serially-connected PMOS devices operating in the subthreshold region for implementing ultra-highvalue resistors required in very low-frequency active-RC filters and bio-amplifiers. Depending on the application, signal bandwidth for instance in bio-amplifiers may vary from a few mHz up to a maximum of 10 kHz. Three different resistor structures are proposed to achieve ultra-high resistance. While ranging in the order of several TY, the proposed ultra-high-resistance pseudoresistors occupy a small on-chip silicon area, which is one of the main issues in the design of analog front-end circuits in ultra-low power implantable biomedical microsystems. In addition, these ultra-high-value resistors lead to the use of a small capacitance to create a very small cut-off frequency. Therefore, the large area to implement capacitances is also considerably reduced. The proposed resistor structures have very small variations about 7% and 12% in a wide input voltage range (-0.5 V +0.5 V), thus significantly improving the total harmonic distortion of bioamplifiers and the analog front-end of the system. Simulation results of different circuits designed in a 180nm CMOS technology, are shown to demonstrate the advantages of the proposed ultra-high-resistance pseudo-resistors.