The main objective of this study is to investigate the airflow characteristics in single-sided ventilation. A CFD method of large eddy simulation (LES) using particle track technique was conducted in this study, and the simulation results are validated by experiment results. The mostly used ventilation efficiency indicators of natural ventilation are Air Flow Rate (AFR) and Purging Flow Rate (PFR). AFR is the volumetric airflow exchange rate through the openings and PFR is the effective airflow rate that removes indoor air pollutants. The ventilation efficiency (ϵν) of natural ventilation, which is defined as the ratio of PFR and AFR, is not well investigated in previous research, therefore, this study discusses the case of the ϵν of single-sided ventilation and tries to explain the distinction between AFR and PFR by statistical analysis approach based on particle movements. Particles are emitted from the opening and the particles' movements are tracked by tracing their locations at different time steps. The residence time measures the time between the time that particles enter the room and the time that particles leave the room, and indoor travel distance indicates the sum of the displacement when the particle travels in the room. The Probability Density Function (PDF) of the residence time and indoor travel distance is used to depict airflow characteristics of the ventilation path of single-sided ventilation. The analysis method of study might be another useful approach to studying natural ventilation in detail.