hig.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard-cite-them-right
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • sv-SE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • de-DE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Association of sarcopenia and its defining components with the degree of cognitive impairment in a memory clinic population
Karolinska University Hospital, Stockholm, Sweden; The Swedish School of Sport and Health Science, GIH, Stockholm, Sweden.
Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden;The Swedish School of Sport and Health Science, GIH, Stockholm, Sweden;Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Karolinska University Hospital, Stockholm, Sweden;Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
Department of Neurobiology, Division of Clinical Geriatrics, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden;Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.
Show others and affiliations
2023 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 96, no 2, p. 777-788Article in journal (Refereed) Published
Abstract [en]

Background: Sarcopenia and cognitive impairment are two leading causes of disabilities.

Objective: The objective was to examine the prevalence of sarcopenia and investigate the association between sarcopenia diagnostic components (muscle strength, muscle mass, and physical performance) and cognitive impairment in memory clinic patients.Methods:368 patients were included (age 59.0±7.25 years, women: 58.7%), displaying three clinical phenotypes of cognitive impairments, i.e., subjective cognitive impairment (SCI, 57%), mild cognitive impairment (MCI, 26%), and Alzheimer’s disease (AD, 17%). Sarcopenia was defined according to diagnostic algorithm recommended by the European Working Group on Sarcopenia in Older People. Components of sarcopenia were grip strength, bioelectrical impedance analysis, and gait speed. They were further aggregated into a score (0–3 points) by counting the numbers of limited components. Multi-nominal logistic regression was applied.

Results: Probable sarcopenia (i.e., reduced grip strength) was observed in 9.6% of the patients, and 3.5% were diagnosed with sarcopenia. Patients with faster gait speed showed less likelihood of MCI (odds ratio [OR]: 0.24, 95% confidence interval [CI]: 0.06–0.90) and AD (OR: 0.12, 95% CI: 0.03–0.60). One or more limited sarcopenia components was associated with worse cognitive function. After adjusting for potential confounders, the association remained significant only for AD (OR 4.29, 95% CI 1.45–11.92).

Conclusion: The results indicate a connection between the sarcopenia components and cognitive impairments. Limitations in the sarcopenia measures, especially slow walking speed, were related to poorer cognitive outcomes. More investigationsare required to further verify the causal relationship between sarcopenia and cognitive outcomes.

Place, publisher, year, edition, pages
IOS Press , 2023. Vol. 96, no 2, p. 777-788
National Category
Clinical Medicine
Identifiers
URN: urn:nbn:se:hig:diva-43206DOI: 10.3233/jad-221186ISI: 001099536400028PubMedID: 37899056Scopus ID: 2-s2.0-85176971451OAI: oai:DiVA.org:hig-43206DiVA, id: diva2:1809674
Funder
Swedish Research Council, 2022-01404Knowledge Foundation, 2018-0151Knowledge Foundation, 2021-0002Knowledge Foundation, 2022-0202Available from: 2023-11-05 Created: 2023-11-05 Last updated: 2023-12-21Bibliographically approved

Open Access in DiVA

fulltext(572 kB)40 downloads
File information
File name FULLTEXT01.pdfFile size 572 kBChecksum SHA-512
6aafe79b5f59015c766d9084e3c54f6f6f84e0225e7f6ee44d2f9a613ab26679bdc02a1fb671abbfc0dda390ae9401baebad5723a1ca0f2a8091323df876192d
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedScopus

Authority records

Thunborg, Charlotta

Search in DiVA

By author/editor
Thunborg, Charlotta
By organisation
Caring Science
In the same journal
Journal of Alzheimer's Disease
Clinical Medicine

Search outside of DiVA

GoogleGoogle Scholar
Total: 40 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 151 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard-cite-them-right
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • sv-SE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • de-DE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf