Here, it is presented a possible methodology and experimental model for benchmarking of air quality in cities. The concept behind the methodology is that a city’s inherent structure affects the potential for contaminant removal due to the resistance it poses to inflow. The approach is based on homogenous emission across the street surface network, representing a worst-case situation. Different levels of complexity can be used for benchmarking, making it valuable for evaluating different layouts. Additionally, an urban ventilation index suitable for these kinds of experimental studies has been suggested.