The pearl oyster Pinctada martensii or Pinctada fucata is the oyster for produce the South China Sea Pearl, and the production of pearl oyster Pinctada martensii plays a key role for the economic and social welfare of the coastal areas. To guarantee both rich and sustainability of providing pearl oyster productions, addressing the suitable areas for aquaculture is a very important consideration in any aquaculture activities. Relatively rarely, in the case of site selection research, the researchers use GIS analysis to identify suitable sites in fishery industry in China. Therefore, I decided to help the local government to search suitable sites form the view of GIS context. This study was conducted to find the optimal sites for suspended culture of pearl oyster Pinctada martensii using GIS-based multi-criteria analysis. The original idea came from the research of Radiarta and his colleagues in 2008 in Japan. Most of the parameters in the GIS model were extracted from remote sensing data (Moderate Resolution Imaging Spectroradiometer and Landsat 7). Eleven thematic layers were arranged into three sub-models, namely: biophysical model, social-economic model and constraint model. The biophysical model includes sea surface temperature, chlorophyll-α concentration, suspended sediment concentration and bathymetry. The criteria in the social-economic model are distance to cities and towns and distance to piers. The constraint model was used to exclude the places from the research area where the natural conditions cannot be fulfilled for the development of pearl oyster aquaculture; it contains river mouth, tourism area, harbor, salt fields / shrimp ponds, and non-related water area. Finally those GIS sub-models were used to address the optimal sites for pearl oyster Pinctada martensii culture by using weighted linear combination evaluation. In the final result, suitability levels were arranged from 1 (least suitable) to 8 (most suitable), and about 2.4% of the total potential area had the higher levels (level 6 and 7). These areas were considered to be the places that have the most suitable conditions for pearl oyster Pinctada martensii for costal water of Yingpan.