According to the actual needs of the modern intelligent building,this paper introduces a intelligent meter reading system based on Nios II,which used the field programmable gate array FPGA EP2C35 and wireless transceiver chip nRF905 and then finished the design of the automatic meter reading system of the building.At the same time, it put forward the hardware structure of the system and software design process, customized the soft core processor and different peripheral interface controllers,established RS232 communication protocol,and at last implemented many functions of the electricity meter including real time collection,processing,data storage,wireless transmission and upper computer communication. It provides a new solution for the intelligent management of amodern buildings. © 2010 IEEE.