hig.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard-cite-them-right
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • sv-SE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • de-DE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Conversion of the Mycotoxin Patulin to the Less Toxic Desoxypatulinic Acid by the Biocontrol Yeast Rhodosporidium kratochvilovae Strain LS11
Univ Molise, Campobasso, Italy .
Univ Molise, Campobasso, Italy .
Univ Cadiz, Spain .
Univ Bologna, Italy .
Show others and affiliations
2011 (English)In: Journal of Agricultural and Food Chemistry, ISSN 0021-8561, E-ISSN 1520-5118, Vol. 59, no 21, p. 11571-11578Article in journal (Refereed) Published
Abstract [en]

The infection of stored apples by the fungus Penicillium e., pansum Causes the contamination of fruits and fruit-derived products with the mycotoxin patulin, which is a major issue in food safety Fungal attack can be prevented by beneficial microorganisms, so-called biocontrol agents Previous time-course thin layer chromatography analyses showed that the aerobic incubation of patulin with the biocontrol yeast Rhodosporidium kratochvilovae strain LS11 leads to the disappearance of the mycotoxin spot and the parallel emergence of two new spots, one of which disappears over time In this work, we analyzed the biodegradation of patulin effected by LS11 through HPLC The more stable of the two compounds was purified and characterized by nuclear magnetic resonance as desoxypatulinic acid, whose formation was also quantitated in patulin degradation experiments After R. kratochvilovae LS11 had been incubated m the presence of (13)C-labeled patulin, label was traced to desoxypatulinic acid, thus proving that this compound derives from the metabolization of patulin by the yeast Desoxypatulinic acid was much less toxic than patulin to human lymphocytes and, in contrast to patulin, did not react in vitro with the thiol-bearing tripeptide glutathione The lower toxicity of desoxypatulinic acid is proposed to be a consequence of the hydrolysis of the lactone ring and the loss of functional, groups that react with thiol groups The formation of desoxypatulinic acid from patulin represents a novel biodegradation pathway that is also a detoxification process

Place, publisher, year, edition, pages
2011. Vol. 59, no 21, p. 11571-11578
Keywords [en]
patulin, metabolization, desoxypatulinic acid, detoxification, biocontrol yeast
Identifiers
URN: urn:nbn:se:hig:diva-14088DOI: 10.1021/jf203098vISI: 000296312000025OAI: oai:DiVA.org:hig-14088DiVA, id: diva2:615307
Available from: 2013-04-09 Created: 2013-04-09 Last updated: 2018-03-13Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full text

Authority records BETA

Wright, Sandra A. I.

Search in DiVA

By author/editor
Wright, Sandra A. I.
In the same journal
Journal of Agricultural and Food Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 569 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard-cite-them-right
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • sv-SE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • de-DE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf