The study aim was to determine the effects of input device type, texting style, and screen size on upper extremity muscle activity and neck and wrist posture during a short texting task in college students. Users of a physical keypad produced greater thumb and wrist extensor muscle force than when texting with a touch screen; using a touch screen required greater wrist extension. Texting on either device produced greater finger flexor and wrist extensor muscle force and greater radial deviation when 1 hand/thumb was used, compared to both hands/thumbs. As touch screen size increased, more participants held the device on their lap, and there was a trend for greater muscle force in finger flexors, wrist extensors, and trapezius, and greater wrist extension, ulnar deviation, and cervical spine flexion. Future research can help inform whether the ergonomic stressors observed during texting are associated with the risk of musculoskeletal disorders.