This article considers different perspectives on the treatment of substance use-related dependency, focusing on the importance of a therapeutic relationship, working alliance, counseling, and the use of narrative methods. The article also discusses some unresolved critical issues concerning the possibilities and limitations of acquiring necessary knowledge about substance use-related dependency when using narrative research methods. The main conclusion is that the therapeutic relationship between the therapist and the client is of crucial importance for a positive outcome of treatment and that narrative methods provide a detailed empirical database for analyses of substance use-related dependency.