hig.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard-cite-them-right
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • sv-SE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • de-DE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Post-cardiac arrest serum levels of glial fibrillary acidic protein for predicting neurological outcome
Department of Surgical Sciences, Uppsala University.
Department of Surgical Sciences, Uppsala University.
University of Gävle, Faculty of Health and Occupational Studies, Department of Health and Caring Sciences. Department of Public Health and Caring Sciences, Uppsala University.
Roche Diagnostics GmbH, Penzberg, Germany.
Show others and affiliations
2014 (English)In: Resuscitation, ISSN 0300-9572, E-ISSN 1873-1570, Vol. 85, no 12, 1654-1661 p.Article in journal (Refereed) Published
Abstract [en]

Aim of the study: To investigate serum levels of glial fibrillary acidic protein (GFAP) for evaluation of neurological outcome in cardiac arrest (CA) patients and compare GFAP sensitivity and specificity to that of more studied biomarkers neuron-specific enolas (NSE) and S100B. Method: A prospective observational study was performed in three hospitals in Sweden during 2008-2012. The participants were 125 CA patients treated with therapeutic hypothermia (TH) to 32-34. °C for 24. hours. Samples were collected from peripheral blood (n. =. 125) and the jugular bulb (n. =. 47) up to 108. hours post-CA. GFAP serum levels were quantified using a novel, fully automated immunochemical method. Other biomarkers investigated were NSE and S100B. Neurological outcome was assessed using the Cerebral Performance Categories scale (CPC) and dichotomized into good and poor outcome. Results: GFAP predicted poor neurological outcome with 100% specificity and 14-23% sensitivity at 24, 48 and 72. hours post-CA. The corresponding values for NSE were 27-50% sensitivity and for S100B 21-30% sensitivity when specificity was set to 100%. A logistic regression with stepwise combination of the investigated biomarkers, GFAP, did not increase the ability to predict neurological outcome. No differences were found in GFAP, NSE and S100B levels when peripheral and jugular bulb blood samples were compared. Conclusion: Serum GFAP increase in patients with poor outcome but did not show sufficient sensitivity to predict neurological outcome after CA. Both NSE and S100B were shown to be better predictors. The ability to predict neurological outcome did not increased when combining the three biomarkers.

Place, publisher, year, edition, pages
2014. Vol. 85, no 12, 1654-1661 p.
Keyword [en]
Biomarkers, Cardiac arrest, Prognostication, Therapeutic hypothermia
National Category
Neurology
Identifiers
URN: urn:nbn:se:hig:diva-17580DOI: 10.1016/j.resuscitation.2014.09.007ISI: 000346603700010PubMedID: 25260722Scopus ID: 2-s2.0-84919429966OAI: oai:DiVA.org:hig-17580DiVA: diva2:748882
Projects
Kylhjärtstopp
Available from: 2014-09-22 Created: 2014-09-22 Last updated: 2016-01-27Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Kristofferzon, Marja-Leena
By organisation
Department of Health and Caring Sciences
In the same journal
Resuscitation
Neurology

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 596 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard-cite-them-right
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • sv-SE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • de-DE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf