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Chemosensory perception, symptoms and autonomic responses during chemical exposure in multiple chemical sensitivity
University of Gävle, Centre for Musculoskeletal Research. University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences, Occupational health science.ORCID iD: 0000-0003-4088-0025
Department of Psychology, Umeå University, Umeå, Sweden.
Danish Research Centre for Chemical Sensitivities, Copenhagen University Hospital Gentofte, Gentofte, Denmark; Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
Danish Research Centre for Chemical Sensitivities, Copenhagen University Hospital Gentofte, Gentofte, Denmark.
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2016 (English)In: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 89, no 1, 79-88 p.Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Multiple chemical sensitivity (MCS) is a prevalent medically unexplained symptom characterized by symptom reactions to everyday chemical exposure below hygienic thresholds. The aim of this study was to investigate the expressions of hyper-reactivity in MCS during whole-body exposure to low concentrations of the odorant n-butanol.

METHODS: We exposed 18 participants with MCS and 18 non-ill controls to a low concentration of the odorant n-butanol using an exposure chamber. The first 10 min constituted blank exposure, after which the n-butanol concentration increased and reached a plateau at 11.5 mg/m(3).

RESULTS: MCS participants, compared with controls, reported greater perceived odor intensities, more unpleasantness to the exposure and increasing symptoms over time. MCS participants also expressed higher pulse rate and lower pulse rate variability than controls did. No group differences were found for breathing rate or tonic electrodermal activity responses.

CONCLUSIONS: We conclude that MCS sufferers differ from healthy controls in terms of autonomic responses, symptoms and chemosensory perception during chemical exposure.

Place, publisher, year, edition, pages
2016. Vol. 89, no 1, 79-88 p.
Keyword [en]
Multiple chemical sensitivity, Chemical intolerance, Environmental intolerance, Olfaction, Autonomic nervous system
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:hig:diva-19306DOI: 10.1007/s00420-015-1053-yISI: 000368807400008PubMedID: 25917753ScopusID: 2-s2.0-84952981367OAI: oai:DiVA.org:hig-19306DiVA: diva2:810674
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2011-0396Swedish Research Council Formas, 2010-1401Riksbankens Jubileumsfond, M14-0375:1
Available from: 2015-05-08 Created: 2015-05-08 Last updated: 2016-11-10Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
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More styles
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  • Other locale
More languages
Output format
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