In this theory article, we discuss the virtual dimensions of the human, the avatar, in relation to ontological assumptions within nursing science. Assumptions in nursing science promote a ‘wholistic’ perspective of the human in terms of body, mind and spirit in relation to the environment. However, due to the enhanced technological development and the invention of cyberspace, we pose the critical question of whether the virtual dimension of identity really implicates a ‘wholistic’ view of human kindness or if this has been neglected. Furthermore, we suggest an ontological understanding that grasps new dimensions of humanity. In the article, we discuss the virtual dimensions of the human in relation to ontological assumptions within nursing science under the three headings of The techno-self and virtual identities, Techno-therapy and cyber nursing, and Becoming homo technicus. Due to these reflections, this article contributes to the debate on a postmodern understanding of human living conditions in society. We suggest further theoretical discussions to explore the conceptual and theoretical levels of nursing knowledge as new realities of human existence are introduced in the field. The transition into the digital age of the Internet, with the existence of cyborgs and avatars, is an ontological and epistemological challenge for nursing science that needs to be further investigated.