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Systematic review of quantitative imaging biomarkers for neck and shoulder musculoskeletal disorders
University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences, Occupational health science. University of Gävle, Centre for Musculoskeletal Research. Gold Standard Research Consulting, Bryn Mawr, PA, USA.
University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences, Occupational health science. University of Gävle, Centre for Musculoskeletal Research.ORCID iD: 0000-0002-2741-1868
University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences, Occupational health science. University of Gävle, Centre for Musculoskeletal Research.ORCID iD: 0000-0002-4556-2846
University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences, Occupational health science. University of Gävle, Centre for Musculoskeletal Research. 2Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.ORCID iD: 0000-0001-7543-4397
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2017 (English)In: BMC Musculoskeletal Disorders, ISSN 1471-2474, E-ISSN 1471-2474, Vol. 18, 395Article in journal (Refereed) Published
Abstract [en]

Background

This study systematically summarizes quantitative imaging biomarker research in non-traumatic neck and shoulder musculoskeletal disorders (MSDs). There were two research questions: 1) Are there quantitative imaging biomarkers associated with the presence of neck and shoulder MSDs?, 2) Are there quantitative imaging biomarkers associated with the severity of neck and shoulder MSDs?

Methods

PubMed and SCOPUS were used for the literature search. One hundred and twenty-five studies met primary inclusion criteria. Data were extracted from 49 sufficient quality studies.

Results

Most of the 125 studies were cross-sectional and utilized convenience samples of patients as both cases and controls. Only half controlled for potential confounders via exclusion or in the analysis. Approximately one-third reported response rates. In sufficient quality articles, 82% demonstrated at least one statistically significant association between the MSD(s) and biomarker(s) studied. The literature synthesis suggested that neck muscle size may be decreased in neck pain, and trapezius myalgia and neck/shoulder pain may be associated with reduced vascularity in the trapezius and reduced trapezius oxygen saturation at rest and in response to upper extremity tasks. Reduced vascularity in the supraspinatus tendon may also be a feature in rotator cuff tears. Five of eight studies showed an association between a quantitative imaging marker and MSD severity.

Conclusions

Although research on quantitative imaging biomarkers is still in a nascent stage, some MSD biomarkers were identified. There are limitations in the articles examined, including possible selection bias and inattention to potentially confounding factors. Recommendations for future studies are provided.

Place, publisher, year, edition, pages
2017. Vol. 18, 395
Keyword [en]
MRI, MSD, near-infrared spectroscopy, overuse, pain, PET/CT, thermography
National Category
Environmental Health and Occupational Health
Identifiers
URN: urn:nbn:se:hig:diva-20784DOI: 10.1186/s12891-017-1694-yPubMedID: 10.1186/s12891-017-1694-yScopus ID: 2-s2.0-85029322406OAI: oai:DiVA.org:hig-20784DiVA: diva2:876769
Projects
ImagingBiorev
Available from: 2015-12-04 Created: 2015-12-04 Last updated: 2017-10-04Bibliographically approved

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Gold, JudithHallman, DavidHellström, FredrikBjörklund, MartinCrenshaw, Albert G.Mathiassen, Svend Erik
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CiteExportLink to record
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