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Cohort Effects in the Prevalence and Survival of People with Dementia in a Rural Area in Northern Sweden
Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden; Center for Alzheimer Research at Karolinska Institutet, Stockholm, Sweden; Centre for Research & Development, Uppsala University/County Council of Gävleborg, Sjukhuset i Gävle, Sweden.
University of Gävle, Faculty of Health and Occupational Studies, Department of Health and Caring Sciences, Caring science. Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Aging Research Center (ARC), Karolinska Institutet and Stockholm University, Stockholm, Sweden.
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2016 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 50, no 2, 387-396 p.Article in journal (Refereed) Published
Abstract [en]

Background: Recent studies suggest that trends in cardiovascular risk may result in a decrease in age-specific prevalence of dementia. Studies in rural areas are rare.

Objectives: To study cohort effects in dementia prevalence and survival of people with dementia in a Swedish rural area.

Methods: Participants were from the 1995-1998 Nordanstig Project (NP) (n = 303) and the 2001-2003 Swedish National study on Aging and Care in Nordanstig (SNAC-N) (n = 384). Overall 6-year dementia prevalence and mortality in NP and SNAC-N were compared for people 78 years and older. Logistic regression analyses were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for dementia occurrence using the NP study population as the reference group. Cox regression models were used to analyze time to death.

Results: The crude prevalence of dementia was 21.8% in NP and 17.4% in SNAC-N. When the NP cohort was used as the reference group, the age- and gender-adjusted OR of dementia was 0.71 (95% CI 0.48-1.04) in SNAC-N; the OR was 0.47 (0.24-0.90) for men and 0.88 (0.54-1.44) for women. In the extended model, the OR of dementia was significantly lower in SNAC-N than in the NP cohort as a whole (0.63; 0.39-0.99) and in men (0.34; 0.15-0.79), but not in women (0.81; 0.46-1.44). The Cox regression models indicated that the hazard ratio of dying was lower in the SNAC-N than NP population.

Conclusions: Trends toward a lower prevalence of dementia in high-income countries seem to be evident in this Swedish rural area, at least in men.

Place, publisher, year, edition, pages
2016. Vol. 50, no 2, 387-396 p.
Keyword [en]
Dementia, mortality, prevalence, rural population
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:hig:diva-20887DOI: 10.3233/JAD-150708ISI: 000368929200006PubMedID: 26639970ScopusID: 2-s2.0-84970917672OAI: oai:DiVA.org:hig-20887DiVA: diva2:890296
Funder
Forte, Swedish Research Council for Health, Working Life and WelfareSwedish Research Council
Available from: 2016-01-02 Created: 2015-12-16 Last updated: 2016-11-14Bibliographically approved

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CiteExportLink to record
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