An experiment for estimating Moho depth is carried out based on satellite altimetry and topographic information using the Vening Meinesz-Moritz gravimetric isostatic hypothesis. In order to investigate the possibility and quality of satellite altimetry in Moho determination, the DNSC08GRA global marine gravity field model and the DTM2006 global topography model are used to obtain a global Moho depth model over the oceans with a resolution of 1 degrees x 1 degrees. The numerical results show that the estimated Bouguer gravity disturbance varies from 86 to 767 mGal, with a global average of 747 mGal, and the estimated Moho depth varies from 3 to 39 km with a global average of 19 km. Comparing the Bouguer gravity disturbance estimated from satellite altimetry and that derived by the gravimetric satellite-only model GOGRA04S shows that the two models agree to 13 mGal in root mean square (RMS). Similarly, the estimated Moho depths from satellite altimetry and GOGRA04S agree to 0.69 km in RMS. It is also concluded that possible mean dynamic topography in the marine gravity model does not significantly affect the Moho determination.