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  • 1.
    Dahl, Joanne
    et al.
    University of Gävle, Department of Education and Psychology, Ämnesavdelningen för psykologi.
    Nilsson, Annika
    University of Gävle, Department of Caring Sciences and Sociology, Ämnesavdelningen för vårdvetenskap.
    Evaluation of a randomized preventive behavioural medicine work site intervention for public health workers at risk for developing chronic pain.2001In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 5, no 4, p. 421-432Article in journal (Refereed)
  • 2.
    Flodgren, Gerd M
    et al.
    University of Gävle, Belastningsskadecentrum.
    Crenshaw, Albert G
    University of Gävle, Belastningsskadecentrum.
    Alfredson, Håkan
    Fahlström, Martin
    Hellström, Fredrik B
    University of Gävle, Belastningsskadecentrum.
    Bronemo, Lars
    Djupsjöbacka, Mats
    University of Gävle, Belastningsskadecentrum.
    Glutamate and prostaglandin E2 in the trapezius muscle of female subjects with chronic muscle pain and controls determined by microdialysis.2005In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 9, no 5, p. 511-515Article in journal (Refereed)
    Abstract [en]

    Much is still unknown concerning the mechanisms underlying the development of chronic muscle pain. The presence and magnitude of inflammatory substances and neurotransmitters in chronic painful conditions is not clear. The aims of the present study were to determine, with the use of microdialysis, the interstitial concentrations and the equilibration times for PGE(2) and glutamate in the trapezius muscles of nine female subjects with chronic muscle pain, and nine pain-free age-matched controls. A microdialysis probe was implanted in the upper part of the trapezius muscle and perfused with Ringer-acetate solution at a flow rate of 0.3 muL/min. Samples were obtained every 30 min, during a 4-h rest period. At equilibration, the mean concentrations (+/-SE) of PGE(2) were 0.71 (+/-0.11) ng/mL for the pain-group and 0.97 (+/-0.35) ng/mL for the controls. For glutamate the mean concentrations for the pain-group were 66.3 (+/-13.3) mumol/L and 60.6 (+/-22.9) mumol/L for the controls. For the pain group and the control group, respectively, equilibration for PGE(2) was reached at 180 and 150 min, and for glutamate at 150 and 120 min. The present study showed no differences between groups in the concentrations of PGE(2) and glutamate in the trapezius muscle. Further, it revealed that when using the slow-flow method, a period of at least 2.0-2.5 h is needed, after probe insertion, to reach steady state for glutamate and PGE(2).

  • 3.
    Schomburg, Eike D.
    et al.
    Zentrum Physiologie und Pathophysiologie, Universität Göttingen, Göttingen, Germany.
    Steffens, Heinz
    Zentrum Physiologie und Pathophysiologie, Universität Göttingen, Göttingen, Germany.
    Maznychenko, Andrey V.
    Department of Movement Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Kiev, Ukraine.
    Pilyavskii, Alexander I.
    Department of Movement Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Kiev, Ukraine.
    Hellström, Fredrik
    University of Gävle, Centre for Musculoskeletal Research.
    Kostyukov, Alexander I.
    Department of Movement Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Kiev, Ukraine.
    Maisky, Vladimir A.
    Department of Movement Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Kiev, Ukraine.
    Acute muscle inflammation enhances the monosynaptic reflexes and c-fos expression in the feline spinal cord2007In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 11, no 5, p. 579-586Article in journal (Refereed)
    Abstract [en]

    The aim of this research was to study the changes of the motor reflex activity (monosynaptic reflex (MSR) of the flexor and extensor muscles) and Fos immunoreactivity in lumbo-sacral spinal cord after acute induced myositis of m. gastrocnemius-soleus (GS). The experiments were carried out on ischaemic decerebrated, spinalized in C1 cats. After infiltration of the GS muscle with carrageenan (2%) MSRs of flexors and extensors showed a significant increase in amplitude +127+/-24.5% and +155+/-28.5%, respectively, p<0.05. The exposed effect was initiated within 30 min and achieved a maximum 2.8h after the intramuscular injections of carrageenan. After analysis of dynamics of the MSRs, animals were perfused and c-fos expression in the spinal segments L6-S1 was evaluated. In comparison to sham-operated animals, the number of Fos-immunoreactive (Fos-ir) cells was noticeably increased in the lumbar cord of cats with carrageenan-induced myositis. The labeled cells were concentrated in the ipsilateral laminae I/II, neck of the dorsal horn (V/VI) and intermediate zone (VII), however, clear predominance of their concentration was found in the deep laminae. The effect of muscle inflammation was also expressed as a significant decline in the number of NADPH-d-reactive cells (p<0.05) in ipsilateral laminae I/II of L6/L7. The results show that the input from acutely inflamed muscles may induce an increase of the reflex responsiveness of flexors and extensors which is not mediated via the gamma-spindle-loop and which coincides with a significant increase in c-fos expression in the deep laminae of the lumbar spinal cord.

  • 4.
    Thunberg, Johan
    et al.
    University of Gävle, Belastningsskadecentrum.
    Lyskov, Eugene
    University of Gävle, Belastningsskadecentrum.
    Korotkov, Alexander
    University of Gävle, Belastningsskadecentrum.
    Ljubisavljevic, Milos
    University of Gävle, Belastningsskadecentrum.
    Pakhomov, Sergey
    Katayeva, Galina
    Radovanovic, Sasa
    University of Gävle, Belastningsskadecentrum.
    Medvedev, Sviatoslav
    Johansson, Håkan
    University of Gävle, Belastningsskadecentrum.
    Brain processing of tonic muscle pain induced by infusion of hypertonic saline.2005In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 9, no 2, p. 185-94Article in journal (Refereed)
    Abstract [en]

    Most of the previous studies on the effects of pain on Regional Cerebral Blood Flow (rCBF) had been done with brief cutaneous or intramuscular painful stimuli. The aim of the present study was to investigate the effect on rCBF of long lasting tonic experimental muscle pain. To this end we performed PET investigations ofrCBF following tonic experimentallow back pain induced by continuous intramuscular infusion ofhypertonic (5%) saline (HS) with computer controIled infusion pump into the right erector spinae on L3 level in 19 healthy volunteers. Changes in rCBF were measured with the use of 150 labelled water during four conditions: Baseline (before start of infusion), Early Pain (4 min after start of infusion), Late Pain (20 min after start of infusion) and Post Pain (> 15 min after stop of infusion) conditions.

    Results of S PM analysis showed relative rCBF increase in the right insula and bilateral decrease in the temporo-parieto-occipital cortex during initial phase of painful stimulation (Early Pain) followed by activation of the medial prefrontal region and bilateral inhibition ofinsula, anterior cingulat and dorso-lateral prefrontal cortex mainly in ipsilateral hemisphere during Late Pain conditions. The results show that longer lasting tonic experimental muscle pain elicited by i.m infusion ofHS results in decreases rather than increases in rCBF. Possible explanations for differences found in rCBF during tonic hypertonic saline-induced experimental muscle pain as compared with previous findings are discussed.

  • 5.
    Wiesinger, Birgitta
    et al.
    Dept. of Odontology, Clinical Oral Physiology, Umeå University.
    Häggman-Henrikson, Birgitta
    Dept. of Odontology, Clinical Oral Physiology, Umeå University.
    Hellström, Fredrik
    University of Gävle, Faculty of Health and Occupational Studies, Department of Occupational and Public Health Sciences, Occupational health science. University of Gävle, Centre for Musculoskeletal Research.
    Wänman, Anders
    Dept. of Odontology, Clinical Oral Physiology, Umeå University.
    Experimental masseter muscle pain alters jaw-neck motor strategy2013In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 17, no 7, p. 995-1004Article in journal (Refereed)
    Abstract [en]

    BACKGROUND:

    A functional integration between the jaw and neck regions has been demonstrated during normal jaw function. The effect of masseter muscle pain on this integrated motor behaviour in man is unknown. The aim of this study was to investigate the effect of induced masseter muscle pain on jaw-neck movements during a continuous jaw opening-closing task.

    METHODS:

    Sixteen healthy men performed continuous jaw opening-closing movements to a target position, defined as 75% of the maximum jaw opening. Each subject performed two trials without pain (controls) and two trials with masseter muscle pain, induced with hypertonic saline as a single injection. Simultaneous movements of the mandible and the head were registered with a wireless optoelectronic three-dimensional recording system. Differences in movement amplitudes between trials were analysed with Friedman's test and corrected Wilcoxon matched pairs test.

    RESULTS:

    The head movement amplitudes were significantly larger during masseter muscle pain trials compared with control. Jaw movement amplitudes did not differ significantly between any of the trials after corrected Wilcoxon tests. The ratio between head and jaw movement amplitudes was significantly larger during the first pain trial compared with control.

    CONCLUSIONS:

    Experimental masseter muscle pain in humans affected integrated jaw-neck movements by increasing the neck component during continuous jaw opening-closing tasks. The findings indicate that pain can alter the strategy for jaw-neck motor control, which further underlines the functional integration between the jaw and neck regions. This altered strategy may have consequences for development of musculoskeletal pain in the jaw and neck regions.

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