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  • 1.
    Narusyte, Jurgita
    et al.
    Karolinska institutet.
    Ropponen, Annina
    University of Eastern Finland.
    Silventoinen, Karri
    University of Helsinki.
    Alexanderson, Kristina
    Karolinska institutet.
    Kaprio, Jaakko
    University of Helsinki; National Institute for Health and Welfare, Helsinki, Finland.
    Samuelsson, Åsa
    Karolinska institutet.
    Svedberg, Pia
    Karolinska institutet.
    Genetic Liability to Disability Pension in Women and Men: A Prospective Population-Based Twin Study2011Ingår i: PLOS ONE, E-ISSN 1932-6203, Vol. 6, nr 8, artikel-id e23143Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Previous studies of risk factors for disability pension (DP) have mainly focused on psychosocial, or environmental, factors, while the relative importance of genetic effects has been less studied. Sex differences in biological mechanisms have not been investigated at all.

    Methods: The study sample included 46,454 Swedish twins, consisting of 23,227 complete twin pairs, born 1928–1958, who were followed during 1993–2008. Data on DP, including diagnoses, were obtained from the National Social Insurance Agency. Within-pair similarity in liability to DP was assessed by calculating intraclass correlations. Genetic and environmental influences on liability to DP were estimated by applying discrete-time frailty modeling.

    Results: During follow-up, 7,669 individuals were granted DP (18.8% women and 14.1% men). Intraclass correlations were generally higher in MZ pairs than DZ pairs, while DZ same-sexed pairs were more similar than opposite-sexed pairs. The best-fitting model indicated that genetic factors contributed 49% (95% CI: 39–59) to the variance in DP due to mental diagnoses, 35% (95% CI: 29–41) due to musculoskeletal diagnoses, and 27% (95% CI: 20–33) due to all other diagnoses. In both sexes, genetic effects common to all ages explained one-third, whereas age-specific factors almost two-thirds, of the total variance in liability to DP irrespective of diagnosis. Sex differences in liability to DP were indicated, in that partly different sets of genes were found to operate in women and men, even though the magnitude of genetic variance explained was equal for both sexes.

    Conclusions: The findings of the study suggest that genetic effects are important for liability to DP due to different diagnoses. Moreover, genetic contributions to liability to DP tend to differ between women and men, even though the overall relative contribution of genetic influences does not differ by sex. Hence, the pathways leading to DP might differ between women and men.

  • 2.
    Ropponen, Annina
    et al.
    Finnish Institute of Occupational Health, Helsinki, Finland.
    Samuelsson, Åsa
    Karolinska institutet.
    Alexanderson, Kristina
    Karolinska institutet.
    Svedberg, Pia
    Karolinska institutet.
    Register-based data of psychosocial working conditions and occupational groups as predictors of disability pension due to musculoskeletal diagnoses: a prospective cohort study of 24 543 Swedish twins2013Ingår i: BMC Musculoskeletal Disorders, E-ISSN 1471-2474, Vol. 14, artikel-id 268Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background. Occupations and psychosocial working conditions have rarely been investigated as predictors of disability pension in population-based samples. This study investigated how occupational groups and psychosocial working conditions are associated with future disability pension due to musculoskeletal diagnoses, accounting for familial factors in the associations.

    Methods. A sample of 24 543 same-sex Swedish twin individuals was followed from 1993 to 2008 using nationwide registries. Baseline data on occupations were categorized into eight sector-defined occupational groups. These were further used to reflect psychosocial working conditions by applying the job strain scores of a Job Exposure Matrix. Cox proportional hazard ratios (HR) were estimated.

    Results. During the 12-year (average) follow-up, 7% of the sample was granted disability pension due to musculoskeletal diagnoses. Workers in health care and social work; agriculture, forestry and fishing; transportation; production and mining; and the service and military work sectors were two to three times more likely to receive a disability pension than those in the administration and management sector. Each single unit decrease in job demands and each single unit increase in job control and social support significantly predicted disability pension. Individuals with high work strain or an active job had a lower hazard ratio of disability pension, whereas a passive job predicted a significantly higher hazard ratio. Accounting for familial confounding did not alter these results.

    Conclusion. Occupational groups and psychosocial working conditions seem to be independent of familial confounding, and hence represent risk factors for disability pension due to musculoskeletal diagnoses. This means that preventive measures in these sector-defined occupational groups and specific psychosocial working conditions might prevent disability pension due to musculoskeletal diagnoses.

  • 3.
    Samuelsson, Åsa
    Karolinska institutet.
    Flexible employment and its relations with work characteristics, union- and family formation and health: From a gender perspective2008Självständigt arbete på avancerad nivå (konstnärlig magisterexamen)Studentuppsats (Examensarbete)
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  • 4.
    Samuelsson, Åsa
    Karolinska institutet.
    Risk factors for disability pension: Studies of a Swedish twin cohort2013Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
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  • 5.
    Samuelsson, Åsa
    et al.
    Karolinska institutet.
    Alexanderson, K.
    Karolinska institutet.
    Ropponen, A.
    University of Eastern Finland.
    Lichtenstein, P.
    Karolinska institutet.
    Svedberg, P.
    Karolinska institutet.
    Incidence of disability pension and associations with socio-demographic factors in a Swedish twin cohort2012Ingår i: Social Psychiatry and Psychiatric Epidemiology, ISSN 0933-7954, E-ISSN 1433-9285, Vol. 47, s. 1999-2009Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose

    The incidence of disability pension (DP), especially due to mental diagnoses, has increased in many countries, but knowledge of socio-demographic risk factors for DP is limited. Further, the influences of genetics and early-life factors (jointly called familial factors) on these associations remain to be studied. The aims were to study incidence of DP (due to all and mental diagnoses) and associations with socio-demographic factors, and also to establish whether associations differ with DP diagnosis and sex, and are influenced by familial factors.

    Methods

    A prospective cohort study of all twins born in 1928–1958 (n = 52,609) in Sweden was conducted. The twins were followed from 1993 to 2008 regarding DP. Cox proportional hazard models were applied.

    Results

    The cumulative incidence of DP was 17 %. Of all the DP diagnoses 20 % were mental. Higher age (≥45 years), being a woman or unmarried, and/or living in a semi-urban area were risk factors for DP. Low education, being a blue-collar worker or being self-employed predicted either higher (all diagnoses) or lower (mental diagnoses) risk of DP. Rural areas were associated with DP due to mental diagnoses. The estimates varied for men and women. After adjustment for familial factors the associations of DP with education and marital status were attenuated and no longer significant. Similar results were apparent for DP due to mental diagnoses and socioeconomic status.

    Conclusions

    Familial factors may select individuals into some of the established risk environments for DP. Studies investigating the causes of DP need to take such confounding into account.

  • 6. Samuelsson, Åsa
    et al.
    Houkes, I
    Verdonk, P
    Hammarström, A
    Type of employment, gender, working conditions and health2009Konferensbidrag (Övrigt vetenskapligt)
  • 7.
    Samuelsson, Åsa
    et al.
    Karolinska Institutet.
    Houkes, Inge
    Maastricht University, The Netherlands.
    Verdonk, Petra
    VU University Medical Center, Department of Medical Humanities, EMGO, Institute for Health and Care Research, Amsterdam, The Netherlands.
    Hammarström, Anne
    Umeå University.
    Types of employment and their associations with work characteristics and health in Swedish women and men2012Ingår i: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 40, nr 2, s. 183-190Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Aim: To investigate whether type of employment was related to work characteristics and health status at age 42 adjusted for health status at age 30 and whether gender moderates the associations.

    Methods: Questionnaire data was used from a 27-year follow-up study of school-leavers carried out in Luleå in the north of Sweden (response rate 94%). The study population consisted of 877 (47.8% women) working respondents. Data were analysed by means of t-tests, ANOVAs, and multiple linear regression analyses.

    Results: Men were more often self-employed, while more women had temporary types of employment. Moreover, men reported more control over work and less emotional exhaustion than women. Compared to permanently employed, self-employed (men and women) perceived more control over work and better health status (p<0.01). Self-employed men also reported more demands and social support (p<0.05). People in temporary types of employment, however, reported less job control, as well as lower health status (only men) (p<0.01). Poor self-reported health and emotional exhaustion were significantly (p<0.05) associated with poor work characteristics (more demands, lower job control, and lower support).

    Conclusions: No direct associations between type of employment and health were found for women and men. However we find indications of an influence of type of employment on work and thereupon health, with job control playing an important role.

  • 8. Samuelsson, Åsa
    et al.
    Ropponen, A
    Alexanderson, K
    Lichtenstein, P
    Svedberg, P
    Occurrence and characteristics of disability pensioners - a prospective cohort study of 56 000 twins followed for 15 years2009Konferensbidrag (Övrigt vetenskapligt)
  • 9. Samuelsson, Åsa
    et al.
    Ropponen, A
    Alexanderson, K
    Svedberg, P
    Incidence of disability pension and associations with sociodemographic factors in a Swedish twin cohort2011Konferensbidrag (Övrigt vetenskapligt)
  • 10. Samuelsson, Åsa
    et al.
    Ropponen, A
    Alexanderson, K
    Svedberg, P
    Psychosocial working conditions and risk of disability pension due to mental diagnoses: a prospective twin cohort study2012Konferensbidrag (Övrigt vetenskapligt)
  • 11.
    Samuelsson, Åsa
    et al.
    Karolinska institutet.
    Ropponen, Annina
    University of Eastern Finland.
    Alexanderson, Kristina
    Karolinska institutet.
    Lichtenstein, Paul
    Karolinska institutet.
    Svedberg, Pia
    Disability Pension Among Swedish Twins - Prevalence Over 16 Years and Associations With Sociodemographic Factors in 19922012Ingår i: Journal of Occupational and Environmental Medicine, ISSN 1076-2752, E-ISSN 1536-5948, Vol. 54, nr 1, s. 10-16Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: To investigate annual prevalence of disability pension (DP) from 1992 to 2007 and associations with sociodemographic factors in 1992.

    Methods: All twins born between 1928 and 1958 were identified from the Swedish Twin Registry and linked to national records on DP. Descriptive statistics and logistic regressions were applied.

    Results: The annual prevalence of DP was 10.7% (9.6% to 11.3%). High age (odds ratio [OR] 9.17; 95% confidence interval [CI] 8.43 to 9.98), low education (OR 4.84; 95% CI 4.31 to 5.42), and being unmarried (OR 2.36; 95% CI 2.22 to 2.50) were associated with DP. The associations remained after adjusting for familial factors.

    Conclusions: The fact that the associations remained after control for familial factors indicates that factors not shared by family members, such as choices in adulthood, are of relevance for the associations found.

  • 12.
    Samuelsson, Åsa
    et al.
    Karolinska institutet.
    Ropponen, Annina
    University of Eastern Finland; Finnish Institute of Occupational Health, Helsinki, Finland.
    Alexanderson, Kristina
    Karolinska institutet.
    Svedberg, Pia
    Karolinska institutet.
    A prospective cohort study of disability pension due to mental diagnoses: the importance of health factors and behaviors2013Ingår i: BMC Public Health, E-ISSN 1471-2458, Vol. 13, artikel-id 621Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background

    Previous studies have found associations between various health factors and behaviors and mental disorders. However, knowledge of such associations with disability pension (DP) due to mental diagnoses is scarce. Moreover, the influence of familial factors (genetics and family background) on the associations are mainly unknown. The aim of the study was to investigate associations between health factors and behaviors and future DP due to mental diagnoses in a twin cohort, accounting for familial confounding.

    Methods

    A prospective cohort study of Swedish twins (N=28 613), including survey data and national register data on DP and other background factors was conducted. Cox proportional hazards regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI) for the whole twin cohort, and for discordant twin pairs.

    Results

    During follow-up 1998–2008 (median 10 years), 2.2% of the cohort was granted a DP with a mental diagnosis. In the fully adjusted analyses of the whole cohort, the associations of poor or moderate self-rated health (SRH), under- or overweight, former or current tobacco use, or being an abstainer from alcohol were significantly associated with risk of DP due to mental diagnoses. Analyses of discordant twin pairs confirmed all these associations, except for current tobacco use, being independent from familial confounding. Exclusion of individuals with current or previous depression or anxiety at baseline did not influence the associations found.

    Conclusions

    Poor or moderate SRH, under- or overweight, former tobacco use or being an abstainer from alcohol seem to be strong direct predictors of DP due to mental diagnoses, independently of several confounders of this study, including familial factors.

  • 13.
    Samuelsson, Åsa
    et al.
    Karolinska institutet.
    Ropponen, Annina
    University of Eastern Finland.
    Alexanderson, Kristina
    Karolinska institutet.
    Svedberg, Pia
    Karolinska institutet.
    Psychosocial working conditions, occupational groups, and risk of disability pension due to mental diagnoses: a cohort study of 43 000 Swedish twins2012Ingår i: Scandinavian Journal of Work, Environment and Health, ISSN 0355-3140, E-ISSN 1795-990X, Vol. 39, nr 4, s. 351-360Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objectives

    The aim of this study was to investigate associations between psychosocial working conditions, occupational groups defined by sector, and disability pension (DP) with mental diagnoses while accounting for familial confounding.

    Methods

    A prospective population-based cohort study was conducted, including all Swedish twins who, in January 1993, were living and working in Sweden and not on old-age pension or DP (N=42 715). The twins were followed from 1993–2008 regarding DP. Data on DP, exposures, and covariates were obtained from national registries. Cox proportional hazards regression models with hazard ratios (HR) and 95% confidence intervals (95% CI) were constructed for the whole cohort, and for discordant twin pairs.

    Results

    The associations for the whole cohort between DP with mental diagnoses and (i) job demands (HR 1.23, 95% CI 1.06–1.43), (ii) job control (HR 0.91, 95% CI 0.83–0.99), (iii) healthcare and social work (HR 1.41, 95% CI 1.04–1.92), and (iv) service and military work (HR 2.07, 95% CI 1.37–3.14) remained after accounting for possible confounders, including familial factors, while the associations between DP and (i) social support, (ii) type of jobs, and (iii) some of the occupational groups were attenuated, becoming non-significant. In the discordant twin pair analyses, commercial work was significantly associated with lower risk of DP (HR 0.55, 95% CI 0.32–0.95).

    Conclusions

    One unit increase in job demands and working in the occupational groups healthcare and social work or service and military work seem to be risk factors of DP with mental diagnoses, independent from various background factors including familial ones. However, one unit increase in job control or working in commercial work seem to be protective factors of such DP, accounting for confounding factors of this study.

  • 14.
    Samuelsson Ökmengil, Åsa
    Karolinska institutet.
    Doktorandombudets rapport – verksamhetsåret 20182018Rapport (Övrigt vetenskapligt)
  • 15.
    Samuelsson Ökmengil, Åsa
    Karolinska institutet.
    Doktorandombudets rapport – verksamhetsåret 20192019Rapport (Övrigt vetenskapligt)
  • 16. Samuelsson Ökmengil, Åsa
    et al.
    Fernström, Å
    Sandberg, J
    Albertsen, L
    Olsson Bohlin, C
    Att förebygga sjukfrånvaro – En sammanställning av möjliga åtgärder2016Rapport (Övrigt vetenskapligt)
  • 17.
    Svedberg, Pia
    et al.
    Karolinska institutet.
    Narusyte, Jurgita
    Karolinska institutet.
    Samuelsson, Åsa
    Karolinska institutet.
    Ropponen, Annina
    Karolinska institutet.
    Lichtenstein, Paul
    Karolinska institutet.
    Alexandersson, Kristina
    Karolinska institutet.
    Betydelsen av arv och miljö för sjukskrivning och sjukersättning bland kvinnor och män i en kohort av svenska tvillingar: Delrapport 8 i projekt om kvinnors och mäns sjukfrånvaro2011Rapport (Övrigt vetenskapligt)
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1 - 17 av 17
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  • sv-SE
  • en-GB
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  • html
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  • asciidoc
  • rtf