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  • 1.
    Björklund, Martin
    et al.
    Högskolan i Gävle, Belastningsskadecentrum.
    Crenshaw, Albert
    Högskolan i Gävle, Belastningsskadecentrum.
    Djupsjöbacka, Mats
    Högskolan i Gävle, Belastningsskadecentrum.
    Johansson, Håkan
    Högskolan i Gävle, Belastningsskadecentrum.
    Position sense acuity is diminished following repetitive low-intensity work to fatigue in a simulated occupational setting. A critical comment2003Ingår i: European Journal of Applied Physiology and Occupational Physiology, ISSN 0301-5548, E-ISSN 1432-1025, Vol. 88, nr 4-5, s. 485-486Artikel i tidskrift (Refereegranskat)
  • 2.
    Björklund, Martin
    et al.
    Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Radovanovic, Sasa
    Ljubisavljevic, Milos
    Windhorst, Uve
    Johansson, Håkan
    Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Effects of combined mechanical and nociceptive stimuli on nociceptive-responsive dorsal horn neurons of cat spinal cord2000Konferensbidrag (Refereegranskat)
    Abstract [en]

    The effects of large ramp and hold stretch of the gastrocnemius muscles were studied on dorsal horn nociceptive-responsive neurons (DHN) in decerebrated cats. The stretch consisted of 3 subsequent plateaus, ending with a release phase from a near maximal physiological length of the muscle. This was done in order to mimic the "therapeutical stretches" used in clinical settings to alleviate muscle tenderness and stiffness. Stretch was applied before and after i.a. injection of bradykinin (50 microg.) into the gastrocnemius muscles. Changes in DHN activity were extracellularly recorded with high impedance glass microelectrodes. Only neurons up to approximately 1 mm were recorded. Neurons were identified as nociceptive on the basis of their response to an identification procedure applied on beforehand. Responsiveness of the DHN to stretch was variable. If responsive, a typical behavior was an increased firing rate during the ramp phases, followed by a gradual decrease during the hold phases and a reduction in firing rate or a complete silence during and after the release phase, usually lasting up to 50 s. Bradykinin injections induced either excitation or inhibition of DHN.. Stretch applied directly after the bradykinin injection in most cases elicited changes in the bradykinin-induced response of the DHN, changing both response profile as well as its strength. Results indicate that nociceptive-responding DHN could be influenced by innocuous ramp and hold stretch both in conjunction with and without chemically induced activation. The behavior of the DHN to stretch in the presence of the painful stimuli may be one of the possible mechanisms that could explain the short term relieving effects of muscle stretching when applied on stiff and tender muscles.

  • 3.
    Bombardi, C.
    et al.
    Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Ozzano dell'Emilia, Italy.
    Grandis, A.
    Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Ozzano dell'Emilia, Italy.
    Chiocchetti, R.
    Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Ozzano dell'Emilia, Italy.
    Bortolami, R.
    Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Ozzano dell'Emilia, Italy.
    Johansson, Håkan
    Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Lucchi, M. L.
    Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Ozzano dell'Emilia, Italy.
    Immunohistochemical localization of alpha(1a)-adrenoreceptors in muscle spindles of rabbit masseter muscle2006Ingår i: Tissue & Cell, ISSN 0040-8166, E-ISSN 1532-3072, Vol. 38, nr 2, s. 121-125Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The expression of alpha(1a)-adrenoreceptors (alpha(1a)-ARs) within the muscle spindles of rabbit masseter muscle was investigated. The alpha(1a)-ARs were detected by immunohistochemical fluorescent method and examined along the entire length of 109 cross serially sectioned spindles. The sympathetic fibers were visualized by the immunofluorescent labeling of the noradrenaline synthesizing enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). In order to recognize the intrafusal muscle fiber types, antibodies for different myosin heavy chain isoforms (MyHCI) were used. TH and DBH immunolabeled nerve fibers have been observed within the capsule lamellar layers, in the periaxial fluid space and close to intrafusal muscle fibers. The alpha(1a)-ARs were detected on the smooth muscle cells of the blood vessels coursing in the muscle and in the capsule lamellar layers or within the periaxial fluid space of the spindles. Moreover, at the polar regions of a high percentage (88.1%) of muscle spindles a strong alpha(1a)-ARs immunoreactivity was present on the intrafusal muscle fibers. In double immunostained sections for alpha(1a)-ARs and MyHCI it was evidenced that both bag, and nuclear chain fibers express alpha(1a)-ARs. The receptors that we have detected by immunofluorescence may support a direct control by adrenergic fibers on muscle spindle.

  • 4.
    Korotkov, Alexander
    et al.
    Högskolan i Gävle, Belastningsskadecentrum.
    Radovanovic, Sasa
    Högskolan i Gävle, Belastningsskadecentrum.
    Ljubisavljevic, Milos
    Högskolan i Gävle, Belastningsskadecentrum.
    Lyskov, Eugene
    Högskolan i Gävle, Belastningsskadecentrum.
    Kataeva, Galina
    Roudas, Marina
    Pakhomov, Sergey
    Thunberg, Johan
    Högskolan i Gävle, Belastningsskadecentrum.
    Medvedev, Sviatoslav
    Johansson, Håkan
    Högskolan i Gävle, Belastningsskadecentrum.
    Comparison of brain activation after sustained non-fatiguing and fatiguing muscle contraction: a positron emission tomography study.2005Ingår i: Experimental Brain Research, ISSN 0014-4819, E-ISSN 1432-1106, Vol. 163, nr 1, s. 65-74Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The concept of fatigue refers to a class of acute effects that can impair motor performance, and not to a single mechanism. A great deal is known about the peripheral mechanisms underlying the process of fatigue, but our knowledge of the roles of the central structures in that process is still very limited. During fatigue, it has been shown that peripheral apparatus is capable of generating adequate force while central structures become insufficient/sub-optimal in driving them. This is known as central fatigue, and it can vary between muscles and different tasks. Fatigue induced by submaximal isometric contraction may have a greater central component than fatigue induced by prolonged maximal efforts. We studied the changes in regional cerebral blood flow (rCBF) of brain structures after sustained isometric muscle contractions of different submaximal force levels and of different durations, and compared them with the conditions observed when the sustained muscle contraction becomes fatiguing. Changes in cortical activity, as indicated by changes in rCBF, were measured using positron emission tomography (PET). Twelve subjects were studied under four conditions: (1) rest condition; (2) contraction of the m. biceps brachii at 30% of MVC, sustained for 60 s; (3) contraction at 30% of MVC, sustained for 120 s, and; (4) contraction at 50% of MVC, sustained for 120 s. The level of rCBF in the activated cortical areas gradually increased with the level and duration of muscle contraction. The fatiguing condition was associated with predominantly contralateral activation of the primary motor (MI) and the primary and secondary somatosensory areas (SI and SII), the somatosensory association area (SAA), and the temporal areas AA and AI. The supplementary motor area (SMA) and the cingula were activated bilaterally. The results show increased cortical activation, confirming that increased effort aimed at maintaining force in muscle fatigue is associated with increased activation of cortical neurons. At the same time, the activation spread to several cortical areas and probably reflects changes in both excitatory and inhibitory cortical circuits. It is suggested that further studies aimed at controlling afferent input from the muscle during fatigue may allow a more precise examination of the roles of each particular region involved in the processing of muscle fatigue.

  • 5.
    Lyskov, Eugene
    et al.
    Högskolan i Gävle, Belastningsskadecentrum.
    Kalezic, Nebojsa
    Högskolan i Gävle, Belastningsskadecentrum.
    Markov, Marko
    Mild, Kjell Hansson
    Thunberg, Johan
    Högskolan i Gävle, Belastningsskadecentrum.
    Johansson, Håkan
    Högskolan i Gävle, Belastningsskadecentrum.
    Low frequency therapeutic EMF differently influences experimental muscle pain in female and male subjects.2005Ingår i: Bioelectromagnetics, ISSN 0197-8462, E-ISSN 1521-186X, Vol. 26, nr 4, s. 299-304Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Effects of a pulsating, half sine wave magnetic field (MF) with a frequency of 100 pps and 15 mT rms flux density, generated by the MD TEMF device (EMF Therapeutics, Inc., Chattanooga), on subjective pain rating, heart rate, and arterial blood pressure were tested in a double blind, crossover design study employing experimental muscle pain. Each of 24 healthy volunteers (12 females and 12 males, 24.7 +/- 3.2 years of age) received painful stimulation induced by the infusion of 5% hypertonic saline (HS) into the erector spinae muscle during real and sham MF exposure, in counterbalanced order. Exposure to MF differently affects subjective pain estimates in females and males. MF exposure increased averaged pain level and time integral of pain ratings in females, whereas no statistically significant difference for these characteristics was found in males. Pain related elevation of systolic and diastolic blood pressure was observed during both real and sham EMF exposure in female and male subjects.

  • 6.
    Radovanovic, Sasa
    et al.
    Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Day, Scott Jason
    Johansson, Håkan
    Högskolan i Gävle, Centrum för belastningsskadeforskning.
    The impact of whole-hand vibration exposure on the sense of angular position about the wrist joint2006Ingår i: International Archives of Occupational and Environmental Health, ISSN 0340-0131, E-ISSN 1432-1246, Vol. 79, nr 2, s. 153-160Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVES: The purpose of this research is to determine the impact of whole-hand vibration on the capacity of subjects to identify previously presented positions of the hand in both wrist flexion and extension. METHODS: In each movement direction, targets of 15 or 30 degrees were presented with an imposed passive movement from the start position. During the second imposed movement, subjects were required to identify when the target position had been reached. For the vibration condition, 15 s of whole-hand vibration exposure was repeated immediately prior to each target position trial. Proprioceptive capacity was assessed by comparing the identified angular position with the reference position-angular distance expressed in terms of absolute error (AE), constant error (CE), and variable error (VE). RESULTS: For three of the four target positions (15 and 30 degrees flexion and 15 degrees extension), the absolute, constant, and VEs of target identification were insensitive to vibration, whereas for the 30 degrees extension target, both the absolute and CE were significantly different before and after the vibration application, showing the subjects overshooting previously presented target position. All three error measures were larger for the long targets than the short targets. CONCLUSIONS: Short-duration exposure to whole-hand vibration is insufficient to compromise post-vibration position sense in the wrist joint, except near the end range of joint movement in wrist extension. Complement contribution of different proprioceptive receptors (muscle, joint, and skin receptors) seems to be crucial for accuracy to reproduce passive movements, since the capacity of any individual class of receptor to deliver information about movement and position of the limbs is limited.

  • 7.
    Söderfjell, Stefan
    et al.
    Högskolan i Gävle, Centrum för belastningsskadeforskning. Department of Psychology, Umeå University, Umeå, Sweden.
    Molander, Bo
    Högskolan i Gävle, Centrum för belastningsskadeforskning. Department of Psychology, Umeå University, Umeå, Sweden.
    Johansson, Håkan
    Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Barnekow-Bergkvist, Margareta
    Högskolan i Gävle, Centrum för belastningsskadeforskning.
    Nilsson, Lars-Göran
    Department of Psychology, Stockholm University, Sweden.
    Musculoskeletal pain complaints and performance on cognitive tasks over the adult life span2006Ingår i: Scandinavian Journal of Psychology, ISSN 0036-5564, E-ISSN 1467-9450, Vol. 47, nr 5, s. 349-359Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The present study aimed at comparing participants with and without self reported musculoskeletal pain in a normal population with regard to performance on a range of tests for episodic memory, semantic memory, and other cognitive functions and to see if expected differences interacted with age. The results showed that participants with pain performed worse on a range of tasks as compared to participants without pain, and that these differences occurred regardless of age. The most robust effects of pain were displayed on tests for vocabulary and construction ability as these were the only effects that remained significant after controlling for years of education and reported depression in separate analyses. When depression and education were controlled for in the same analysis, even these effects were eliminated, suggesting interplay between pain, depressive status, and educational level in the negative effects on cognitive functioning.

  • 8.
    Thunberg, Johan
    et al.
    Högskolan i Gävle, Belastningsskadecentrum.
    Lyskov, Eugene
    Högskolan i Gävle, Belastningsskadecentrum.
    Korotkov, Alexander
    Högskolan i Gävle, Belastningsskadecentrum.
    Ljubisavljevic, Milos
    Högskolan i Gävle, Belastningsskadecentrum.
    Pakhomov, Sergey
    Katayeva, Galina
    Radovanovic, Sasa
    Högskolan i Gävle, Belastningsskadecentrum.
    Medvedev, Sviatoslav
    Johansson, Håkan
    Högskolan i Gävle, Belastningsskadecentrum.
    Brain processing of tonic muscle pain induced by infusion of hypertonic saline.2005Ingår i: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 9, nr 2, s. 185-94Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Most of the previous studies on the effects of pain on Regional Cerebral Blood Flow (rCBF) had been done with brief cutaneous or intramuscular painful stimuli. The aim of the present study was to investigate the effect on rCBF of long lasting tonic experimental muscle pain. To this end we performed PET investigations ofrCBF following tonic experimentallow back pain induced by continuous intramuscular infusion ofhypertonic (5%) saline (HS) with computer controIled infusion pump into the right erector spinae on L3 level in 19 healthy volunteers. Changes in rCBF were measured with the use of 150 labelled water during four conditions: Baseline (before start of infusion), Early Pain (4 min after start of infusion), Late Pain (20 min after start of infusion) and Post Pain (> 15 min after stop of infusion) conditions.

    Results of S PM analysis showed relative rCBF increase in the right insula and bilateral decrease in the temporo-parieto-occipital cortex during initial phase of painful stimulation (Early Pain) followed by activation of the medial prefrontal region and bilateral inhibition ofinsula, anterior cingulat and dorso-lateral prefrontal cortex mainly in ipsilateral hemisphere during Late Pain conditions. The results show that longer lasting tonic experimental muscle pain elicited by i.m infusion ofHS results in decreases rather than increases in rCBF. Possible explanations for differences found in rCBF during tonic hypertonic saline-induced experimental muscle pain as compared with previous findings are discussed.

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