Given that aligning supply chain strategies with changing productcharacteristics across the phases of the product life cycle is increasinglyimportant, this study investigates the changes in supply and demand uncertaintywhen a product enters the decline phase and how these changes in turn affectthe supply chain strategies applied. Based on four case studies, the analysisreveals that the uncertainties increase in three of four cases when the productenters the decline phase, and that the type of uncertainty, as well as the relatedchallenges, depends on the product’s initial uncertainty of supply and demand.This implies that companies need to redesign their supply chain strategiestowards either more lean or more agile supply chains, or combinations thereof,when the products are declining.