During the last few decades, supply chain (SC) strategy has become an important focus for manufacturers. This has resulted in the implementation of a wide variety of SC strategies, including, for example, lean, agile, and leagile – the latter being a combination of the first two. All these and other SC strategies aim at achieving a certain level of responsiveness to customer needs. Since the level of responsiveness should match the characteristics of a product, this chapter discusses how manufacturers can engage in SC strategizing in the context of new product development (NPD). Through the theoretical lens of “strategy-as-practice” (SAP), SC strategizing in NPD is conceptualized as a dynamic interplay of “practitioners,” “activities,” and “practices.” The chapter also explains that, while managing this interplay, manufacturers should be aware of challenges caused by uncertainty, politics, and learning. Finally, the chapter opens the door for future research that utilizes the SAP lens in order to empirically explore SC strategizing in NPD.