Construction and manufacturing workers undertake physically laborious activities which put them at risk of developing serious musculoskeletal disorders (MSDs). In the EU, millions of workers are being affected by workplace-related MSDs, inflicting huge financial implications on the European economy. Besides that, increased health problems and financial losses, severe shortages of skilled labor also emerge. The work aims to create awareness and accelerate the adoption of exoskeletons among SMEs and construction workers to reduce MSDs. Large-scale manufacturers and automobile assemblers are more open to adopt exoskeletons, however, the use of exoskeletons in small and medium enterprises (SMEs) is still not recognized. This paper presents an experimental study demonstrating the advantages of different exoskeletons while performing workers’ tasks. The study illustrates how the use of certain upper and lower body exoskeletons can reduce muscle effort. The muscle activity of the participants was measured using EMG sensors and was compared while performing designated tasks. It was found that up to 60% reduction in human effort can be achieved while performing the same tasks using exoskeletons. This can also help ill workers in rehabilitation and putting them back to work. The study concludes with pragmatic recommendations for future exoskeletons.