Pakistan is affected by floods of various intensities ranging between high, moderate and low levels. The aim of this study is to evaluate the effects of 2022 flood events in Pakistan. This aim will be achieved by analyzing the relationship between the 2022 floods and the situation of affected communities, with a focus on gender roles. The study assessed the differences in vulnerability to floods between men vs. women by examining their socio-economic conditions before and after flood 2022. Multiple field surveys were conducted for data collection, and a questionnaire was used to learn about the current and past conditions of the people living in the villages around the city of Khipro, Sindh, located downstream of the Indus River, majorly affected by floods in terms of lives and livelihoods. Correlations, and cross-tabulations were used to analyze the demographic characteristics and socioeconomic status of communities. Focusing on the period before and after the 2022 floods and the difference in vulnerability, the results of the study indicated that despite having better access to disaster preparedness information and resources, societal norms and mobility issues make women more vulnerable. Therefore, it is important to focus on gender-sensitive disaster preparedness and response efforts. The study proposes a few measures to improve resilience and promote sustainable development in flood-affected areas.