The growth of the neurodiversity movement has brought about new ethical, theoretical, and political debates within autism theory and research. These debates bring forth the pressing issue of developing better practices for neurodiversity-affirmative research. In this chapter, we focus on how R2D2-MH—a large international biomedical project on Risk and Resilience in Developmental Diversity and Mental Health—works with neurodivergent knowledge production. R2D2-MH aims to improve the mental health outcomes of young neurodivergent people across the lifespan. Therefore, this biomedical project made it a priority to work with co-creation groups and explicitly engage with neurodivergent communities. We write from the perspectives of our different roles in R2D2-MH: facilitator and member of the adult co-creation group, and member of R2D2-MH scientific advisory board. We draw on collaborative autoethnographic methodology to explore and reflect upon our experiences of co-creation and neurodiverse (A neurodiverse space is one where multiple neurocognitive styles are represented (Walker, 2021)).