Job rotation is one of the most recommended and practiced organizational interventions for injury prevention and health promotion; however, insufficient evidence is currently available to assess the effectiveness of this work organization approach due to limitations in study design and physical exposure assessment metrics used in prior studies. Future studies are required in which research and company/organizational partners collaborate to evaluate job rotation interventions using relevant metrics including assessment of the impact of job rotation on variation across the full duration of the JR cycle and, subsequently, health. Recommendations are proposed to help guide future study designs and exposure assessment metric selection to support the generation of sufficient data for evidence synthesis.