This article is an attempt to investigate some conceptual underpinnings of cultural dimensions to the design and use of ICT based initiatives in educational settings, particularly in Eastern contexts like Iran, promoting a sociocultural perspective on education, instruction and learning. The article move progressively from clarifying fundamental issues about social and cultural factors on globalizations of education to definitional and operational considerations, and focused on several major issues: Understanding of Culture; Cultural considerations in designing and using ICT in e-learning; Cultural dimensions in E-learning; Characterizing some common traits in Eastern pedagogical cultures. By discussing the challenges and potential opportunities with preference to social and cultural factors in globalization of education, it was pointed that there are certain context-specific social and cultural factors indices - as well as educational attainments – that affect the access to and use of its in developing countries. These factors / dimensions must be recognized and analyzed for the E-learning to be properly adapted and developed.